1-N-(4,4'-dimethoxytrithyl)-D(+)-biotin methyl ester

Base Information

Chemical Name:1-N-(4,4'-dimethoxytrithyl)-D(+)-biotin methyl ester
CAS No.:122224-36-6
Molecular Formula:C₃₂H₃₆N₂O₅S
Molecular Weight:560.714
Hs Code.:

Synonyms:1-N-(4,4'-dimethoxytrithyl)-D(+)-biotin methyl ester

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Chemical Property of 1-N-(4,4'-dimethoxytrithyl)-D(+)-biotin methyl ester

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Technology Process of 1-N-(4,4'-dimethoxytrithyl)-D(+)-biotin methyl ester

There total 2 articles about 1-N-(4,4'-dimethoxytrithyl)-D(+)-biotin methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 608-16-2
biotin methyl ester

: 122224-36-6
1-N-(4,4'-dimethoxytrithyl)-D(+)-biotin methyl ester

Guidance literature:: With pyridine; dmap; triethylamine; at 75 ℃; for 4h;
DOI:10.1021/jo201615j

Reference yield:

: 58-85-5,22879-79-4
biotin

: 122224-36-6
1-N-(4,4'-dimethoxytrithyl)-D(+)-biotin methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂

2: pyridine; Et₃N

With pyridine; thionyl chloride; triethylamine;
DOI:10.1021/ol052484f

Reference yield: 85.0%

: 122224-36-6
1-N-(4,4'-dimethoxytrithyl)-D(+)-biotin methyl ester

: 106-96-7
propargyl bromide

: 1340498-75-0
C₃₅H₃₈N₂O₅S

Guidance literature:: 1-N-(4,4'-dimethoxytrithyl)-D(+)-biotin methyl ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.25h; Inert atmosphere; Cooling with ice;

propargyl bromide; With tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; toluene; mineral oil; at 20 ℃; for 3h; regioselective reaction; Cooling with ice; Inert atmosphere;
DOI:10.1021/jo201615j