6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoic acid

Base Information

• Chemical Name: 6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoic acid
• CAS No.: 874944-64-6
• Molecular Formula: C₃₇H₄₅N₃O₆S
• Molecular Weight: 659.847
• Mol file: 874944-64-6.mol

Synonyms:6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoic acid

Chemical Property of 6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoic acid

There total 7 articles about 6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoate (874889-84-6) → 6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoic acid (874944-64-6)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 22h;

DOI:10.1021/ol052484f

Reference yield:

methyl 6-aminohexanoate hydrochloride (2780-89-4) → 6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoic acid (874944-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.0 g / DCC; pyridine / 20 °C

2: 90 percent / aq. NaOH / methanol / 22 h / 20 °C

With pyridine; sodium hydroxide; dicyclohexyl-carbodiimide; In methanol;

DOI:10.1021/ol052484f

Reference yield:

1-N-(4,4'-dimethoxytrithyl)-D(+)-biotin methyl ester (122224-36-6) → 6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoic acid (874944-64-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.33 g / aq. NaOH / methanol / 17 h

2: 2.0 g / DCC; pyridine / 20 °C

3: 90 percent / aq. NaOH / methanol / 22 h / 20 °C

With pyridine; sodium hydroxide; dicyclohexyl-carbodiimide; In methanol;

DOI:10.1021/ol052484f

upstream raw materials:

methyl 6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoate

methyl 6-aminohexanoate hydrochloride

1-N-(4,4'-dimethoxytrithyl)-D(+)-biotin methyl ester

N¹-4,4'-dimethoxytrityl-(+)-biotin

Downstream raw materials:

2'-O-(bis(2-methoxyethoxy)methyl)-6-N-(4,4'-dimethoxytrityl)-3'-O-(N-(6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoyl)-L-phenylalanyl)adenosine

2'-O-(bis(2-methoxyethoxy)methyl)-6-N-(4,4'-dimethoxytrityl)-3'-O-(N-(6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoyl)-L-[2-2H]phenylalanyl)adenosine

2'-O-(bis(2-methoxyethoxy)methyl)-6-N-(4,4'-dimethoxytrityl)-3'-O-(N-(6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoyl)-L-phenylalanyl)-[2'-18O]adenosine

2'-O-(bis(2-methoxyethoxy)methyl)-6-N-(4,4'-dimethoxytrityl)-3'-O-(N-(6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoyl)-L-phenylalanyl)-[3'-18O]adenosine