(S)-3-{3,5-Diiodo-4-[4-methoxy-5-(6-methoxy-pyridin-3-ylmethyl)-2-methyl-phenoxy]-phenyl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester

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Chemical Name:(S)-3-{3,5-Diiodo-4-[4-methoxy-5-(6-methoxy-pyridin-3-ylmethyl)-2-methyl-phenoxy]-phenyl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester
CAS No.:117896-32-9
Molecular Formula:C₂₈H₂₇F₃I₂N₂O₆
Molecular Weight:798.336
Hs Code.:

Synonyms:(S)-3-{3,5-Diiodo-4-[4-methoxy-5-(6-methoxy-pyridin-3-ylmethyl)-2-methyl-phenoxy]-phenyl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester

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Chemical Property of (S)-3-{3,5-Diiodo-4-[4-methoxy-5-(6-methoxy-pyridin-3-ylmethyl)-2-methyl-phenoxy]-phenyl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester

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Technology Process of (S)-3-{3,5-Diiodo-4-[4-methoxy-5-(6-methoxy-pyridin-3-ylmethyl)-2-methyl-phenoxy]-phenyl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester

There total 7 articles about (S)-3-{3,5-Diiodo-4-[4-methoxy-5-(6-methoxy-pyridin-3-ylmethyl)-2-methyl-phenoxy]-phenyl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105189-48-8
4-methoxy-3-<(6-methoxypyridin-3-yl)methyl>phenol

: 117896-32-9
(S)-3-{3,5-Diiodo-4-[4-methoxy-5-(6-methoxy-pyridin-3-ylmethyl)-2-methyl-phenoxy]-phenyl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1) boric acid, 2) 30percent H₂SO₄ / 1) ethylene glycol, 130 deg C, 0.5 h, 2) 80 deg C to room temperature

2: 75 percent / NaBH₄ / methanol; dioxane / 0.5 h / Ambient temperature

3: pyridine / 1 h / 100 °C

4: 50 percent / NaBH₄ / 1,2-dimethoxy-ethane / 17 h / 45 - 50 °C

5: MeSO₂Cl, pyridine

6: H₂ / Pd/C

7: 1) NaNO₂, H₂SO₄, 2) KI, I₂ / 1) H₂O

With pyridine; sodium tetrahydroborate; sulfuric acid; hydrogen; iodine; boric acid; methanesulfonyl chloride; potassium iodide; sodium nitrite; palladium on activated charcoal; In 1,4-dioxane; methanol; 1,2-dimethoxyethane;
DOI:10.1021/jm00122a009

Reference yield:

: 117653-28-8
2-formyl-4-methoxy-5-<(2-methoxypyrid-5-yl)methyl>phenol

: 117896-32-9
(S)-3-{3,5-Diiodo-4-[4-methoxy-5-(6-methoxy-pyridin-3-ylmethyl)-2-methyl-phenoxy]-phenyl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / NaBH₄ / methanol; dioxane / 0.5 h / Ambient temperature

2: pyridine / 1 h / 100 °C

3: 50 percent / NaBH₄ / 1,2-dimethoxy-ethane / 17 h / 45 - 50 °C

4: MeSO₂Cl, pyridine

5: H₂ / Pd/C

6: 1) NaNO₂, H₂SO₄, 2) KI, I₂ / 1) H₂O

With pyridine; sodium tetrahydroborate; sulfuric acid; hydrogen; iodine; methanesulfonyl chloride; potassium iodide; sodium nitrite; palladium on activated charcoal; In 1,4-dioxane; methanol; 1,2-dimethoxyethane;
DOI:10.1021/jm00122a009

Reference yield:

: 117653-27-7
2-(hydroxymethyl)-4-methoxy-5-<(2-methoxypyrid-5-yl)methyl>phenol

: 117896-32-9
(S)-3-{3,5-Diiodo-4-[4-methoxy-5-(6-methoxy-pyridin-3-ylmethyl)-2-methyl-phenoxy]-phenyl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 1 h / 100 °C

2: 50 percent / NaBH₄ / 1,2-dimethoxy-ethane / 17 h / 45 - 50 °C

3: MeSO₂Cl, pyridine

4: H₂ / Pd/C

5: 1) NaNO₂, H₂SO₄, 2) KI, I₂ / 1) H₂O

With pyridine; sodium tetrahydroborate; sulfuric acid; hydrogen; iodine; methanesulfonyl chloride; potassium iodide; sodium nitrite; palladium on activated charcoal; In 1,2-dimethoxyethane;
DOI:10.1021/jm00122a009