N-Acetyl-2-O-benzyl-neuraminic Acid Methyl Ester

Base Information

• Chemical Name: N-Acetyl-2-O-benzyl-neuraminic Acid Methyl Ester
• CAS No.: 57777-97-6
• Molecular Formula: C₁₉H₂₇NO₉
• Molecular Weight: 413.425
• Mol file: 57777-97-6.mol

Synonyms:methyl (benzyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosid)onate

Chemical Property of N-Acetyl-2-O-benzyl-neuraminic Acid Methyl Ester

Chemical Property:

• Melting Point: 80-82°C
• Storage Temp.: -20?C Freezer
• Solubility.: Chloroform, Methanol

Purity/Quality:

95% ^*data from raw suppliers

N-Acetyl-2-O-benzyl-neuraminic Acid Methyl Ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Neuraminic Acid derivative.

Technology Process of N-Acetyl-2-O-benzyl-neuraminic Acid Methyl Ester

There total 3 articles about N-Acetyl-2-O-benzyl-neuraminic Acid Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl (benzyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosid)onate (19342-75-7) → methyl (benzyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosid)onate (57777-97-6)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2007.04.038

Reference yield:

N-acetyl-4,7,8,9-tetra-O-acetyl-2-chloro-2-deoxyneuraminic acid methyl ester (67670-69-3) → methyl (benzyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosid)onate (57777-97-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Ag₂CO₃; AgClO₄; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

2: MeONa / methanol / 20 °C

With 4 A molecular sieve; sodium methylate; silver perchlorate; silver carbonate; In methanol; dichloromethane;

DOI:10.1055/s-2005-868514

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → methyl (benzyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosid)onate (57777-97-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Ag₂CO₃; AgClO₄; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

2: MeONa / methanol / 20 °C

With 4 A molecular sieve; sodium methylate; silver perchlorate; silver carbonate; In methanol; dichloromethane;

DOI:10.1055/s-2005-868514

upstream raw materials:

methyl (benzyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosid)onate

N-acetyl-4,7,8,9-tetra-O-acetyl-2-chloro-2-deoxyneuraminic acid methyl ester

benzyl alcohol

Downstream raw materials:

(2R,4S,5R,6R)-5-(Acetyl-tert-butoxycarbonyl-amino)-4-benzoyloxy-2-benzyloxy-6-((4S,5R)-5-benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-pyran-2-carboxylic acid methyl ester

(2R,4S,5R,6R)-4-Benzoyloxy-2-benzyloxy-6-((1R,2R)-3-benzyloxy-1,2-dihydroxy-propyl)-5-(2,2,2-trifluoro-acetylamino)-tetrahydro-pyran-2-carboxylic acid methyl ester

(2R,4S,5R,6R)-4-Benzoyloxy-2-benzyloxy-6-((4S,5R)-5-benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-tert-butoxycarbonylamino-tetrahydro-pyran-2-carboxylic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 57777-97-6 N-Acetyl-2-O-benzyl-neuraminic Acid Methyl Ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send