(E)-[(6-dimethylphenylsilyl-7-nonen-1-yl)oxy]triisopropylsilane

Base Information

• Chemical Name: (E)-[(6-dimethylphenylsilyl-7-nonen-1-yl)oxy]triisopropylsilane
• CAS No.: 1378249-74-1
• Molecular Formula: C₂₆H₄₈OSi₂
• Molecular Weight: 432.838
• Mol file: 1378249-74-1.mol

Synonyms:(E)-[(6-dimethylphenylsilyl-7-nonen-1-yl)oxy]triisopropylsilane

Chemical Property of (E)-[(6-dimethylphenylsilyl-7-nonen-1-yl)oxy]triisopropylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-[(6-dimethylphenylsilyl-7-nonen-1-yl)oxy]triisopropylsilane

There total 4 articles about (E)-[(6-dimethylphenylsilyl-7-nonen-1-yl)oxy]triisopropylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C22H45BOSi (1258222-46-6) + 2-{[(2S,3Z)-4-[dimethyl(phenyl)silyl]-3-buten-2-yl]oxy}-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide (1378249-52-5) → (E)-[(6-dimethylphenylsilyl-7-nonen-1-yl)oxy]triisopropylsilane (1378249-74-1)

Guidance literature:

With potassium methanolate; copper (I) acetate; In toluene; at 25 - 80 ℃; for 8h; optical yield given as %ee; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ja302520h

Reference yield:

C17H26O2Si → (E)-[(6-dimethylphenylsilyl-7-nonen-1-yl)oxy]triisopropylsilane (1378249-74-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / methanol / 6 h / 20 °C / Inert atmosphere

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

2.2: 3.08 h / -78 - 20 °C / Inert atmosphere

3.1: potassium methanolate; copper (I) acetate / toluene / 8 h / 25 - 80 °C / Inert atmosphere

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; potassium methanolate; copper (I) acetate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; toluene;

DOI:10.1021/ja302520h

Reference yield:

(S)-(Z)-1-(Dimethylphenylsilyl)-1-buten-3-ol (129158-81-2,133398-24-0,133398-25-1,137120-08-2,142697-15-2,142697-16-3) → (E)-[(6-dimethylphenylsilyl-7-nonen-1-yl)oxy]triisopropylsilane (1378249-74-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

1.2: 3.08 h / -78 - 20 °C / Inert atmosphere

2.1: potassium methanolate; copper (I) acetate / toluene / 8 h / 25 - 80 °C / Inert atmosphere

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; potassium methanolate; copper (I) acetate; In tetrahydrofuran; toluene;

DOI:10.1021/ja302520h

upstream raw materials:

C₂₂H₄₅BOSi

2-{[(2S,3Z)-4-[dimethyl(phenyl)silyl]-3-buten-2-yl]oxy}-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide

(S)-(Z)-1-(Dimethylphenylsilyl)-1-buten-3-ol

triisopropyl(pent-4-en-1-yloxy)silane