2-{[(2S,3Z)-4-[dimethyl(phenyl)silyl]-3-buten-2-yl]oxy}-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide

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Chemical Name:2-{[(2S,3Z)-4-[dimethyl(phenyl)silyl]-3-buten-2-yl]oxy}-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide
CAS No.:1378249-52-5
Molecular Formula:C₁₇H₂₇O₄PSi
Molecular Weight:354.458
Hs Code.:

Synonyms:2-{[(2S,3Z)-4-[dimethyl(phenyl)silyl]-3-buten-2-yl]oxy}-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide

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Chemical Property of 2-{[(2S,3Z)-4-[dimethyl(phenyl)silyl]-3-buten-2-yl]oxy}-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide

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Technology Process of 2-{[(2S,3Z)-4-[dimethyl(phenyl)silyl]-3-buten-2-yl]oxy}-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide

There total 3 articles about 2-{[(2S,3Z)-4-[dimethyl(phenyl)silyl]-3-buten-2-yl]oxy}-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 4090-55-5
2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide

: 129158-81-2,133398-24-0,133398-25-1,137120-08-2,142697-15-2,142697-16-3
(S)-(Z)-1-(Dimethylphenylsilyl)-1-buten-3-ol

: 1378249-52-5
2-{[(2S,3Z)-4-[dimethyl(phenyl)silyl]-3-buten-2-yl]oxy}-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide

Guidance literature:: (S)-(Z)-1-(Dimethylphenylsilyl)-1-buten-3-ol; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at -78 ℃; for 0.75h; Inert atmosphere;

2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide; In tetrahydrofuran; at -78 - 20 ℃; for 3.08333h; Inert atmosphere;
DOI:10.1021/ja302520h

Reference yield:

: 1378249-47-8
C₁₇H₂₄O₂Si

: 1378249-52-5
2-{[(2S,3Z)-4-[dimethyl(phenyl)silyl]-3-buten-2-yl]oxy}-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / diethyl ether / 22 h / 0 - 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: toluene-4-sulfonic acid / methanol / 6 h / 20 °C / Inert atmosphere

3.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

3.2: 3.08 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; diisobutylaluminium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/ja302520h

Reference yield:

: C₁₇H₂₆O₂Si

: 1378249-52-5
2-{[(2S,3Z)-4-[dimethyl(phenyl)silyl]-3-buten-2-yl]oxy}-5,5-dimethyl-1,3,2-dioxaphosphinane-2-oxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / methanol / 6 h / 20 °C / Inert atmosphere

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

2.2: 3.08 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; toluene-4-sulfonic acid; In tetrahydrofuran; methanol;
DOI:10.1021/ja302520h