(2-amino-6-{2-[(cyclopropylmethylamino)methyl]phenyl}quinazolin-4-yl)-(1,3-dihydroisoindol-2-yl)methanone

Base Information

Chemical Name:(2-amino-6-{2-[(cyclopropylmethylamino)methyl]phenyl}quinazolin-4-yl)-(1,3-dihydroisoindol-2-yl)methanone
CAS No.:1367454-77-0
Molecular Formula:C₂₈H₂₇N₅O
Molecular Weight:449.555
Hs Code.:

Synonyms:(2-amino-6-{2-[(cyclopropylmethylamino)methyl]phenyl}quinazolin-4-yl)-(1,3-dihydroisoindol-2-yl)methanone

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Chemical Property of (2-amino-6-{2-[(cyclopropylmethylamino)methyl]phenyl}quinazolin-4-yl)-(1,3-dihydroisoindol-2-yl)methanone

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Technology Process of (2-amino-6-{2-[(cyclopropylmethylamino)methyl]phenyl}quinazolin-4-yl)-(1,3-dihydroisoindol-2-yl)methanone

There total 7 articles about (2-amino-6-{2-[(cyclopropylmethylamino)methyl]phenyl}quinazolin-4-yl)-(1,3-dihydroisoindol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1228311-57-6
[2-amino-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone

: 1247180-19-3
(2-bromobenzyl)cyclopropylmethylamine

: 1367454-77-0
(2-amino-6-{2-[(cyclopropylmethylamino)methyl]phenyl}quinazolin-4-yl)-(1,3-dihydroisoindol-2-yl)methanone

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In ethanol; water; at 120 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: 1367454-77-0
(2-amino-6-{2-[(cyclopropylmethylamino)methyl]phenyl}quinazolin-4-yl)-(1,3-dihydroisoindol-2-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / tetrahydrofuran; 1,2-dichloro-ethane / 6 h / 60 °C

1.2: 12 h / 25 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / Cooling with ice

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / ethanol; water / 0.5 h / 120 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydride; potassium carbonate; acetic acid; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane; mineral oil; 3.1: |Suzuki Coupling;

Reference yield:

: 90868-91-0
N-(2-bromobenzyl)cyclopropanamine

: 1367454-77-0
(2-amino-6-{2-[(cyclopropylmethylamino)methyl]phenyl}quinazolin-4-yl)-(1,3-dihydroisoindol-2-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / Cooling with ice

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / ethanol; water / 0.5 h / 120 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydride; potassium carbonate; In tetrahydrofuran; ethanol; water; mineral oil; 2: |Suzuki Coupling;