(5R)-1-(o-tert-butyldiphenylsiloxyphenyl)-5-(methoxymethyl)-2-pyrrolidinone

Base Information

Chemical Name:(5R)-1-(o-tert-butyldiphenylsiloxyphenyl)-5-(methoxymethyl)-2-pyrrolidinone
CAS No.:261911-57-3
Molecular Formula:C₂₈H₃₃NO₃Si
Molecular Weight:459.66
Hs Code.:

Synonyms:(5R)-1-(o-tert-butyldiphenylsiloxyphenyl)-5-(methoxymethyl)-2-pyrrolidinone

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Chemical Property of (5R)-1-(o-tert-butyldiphenylsiloxyphenyl)-5-(methoxymethyl)-2-pyrrolidinone

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Technology Process of (5R)-1-(o-tert-butyldiphenylsiloxyphenyl)-5-(methoxymethyl)-2-pyrrolidinone

There total 5 articles about (5R)-1-(o-tert-butyldiphenylsiloxyphenyl)-5-(methoxymethyl)-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 261911-56-2
(5R)-1-(o-(benzyloxy)phenyl)-5-(methoxymethyl)-2-pyrrolidinone

: 261911-57-3
(5R)-1-(o-tert-butyldiphenylsiloxyphenyl)-5-(methoxymethyl)-2-pyrrolidinone

Guidance literature:: (5R)-1-(o-(benzyloxy)phenyl)-5-(methoxymethyl)-2-pyrrolidinone; With hydrogen; palladium on activated charcoal; In ethyl acetate; for 5h;

tert-butylchlorodiphenylsilane; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 3h; Further stages.;
DOI:10.1021/jo991578y

Reference yield:

: 20012-63-9
o-(benzyloxy)aniline

: 261911-57-3
(5R)-1-(o-tert-butyldiphenylsiloxyphenyl)-5-(methoxymethyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 77 percent / Me₃AL / toluene; hexane / Thermolysis

2.1: Et₃N / CH₂Cl₂

3.1: t-BuOK / toluene / 20 °C

4.1: H₂ / Pd/C / ethyl acetate / 5 h

4.2: 92 percent / NaH / tetrahydrofuran / 3 h / 20 °C

With potassium tert-butylate; hydrogen; trimethylaluminum; triethylamine; palladium on activated charcoal; In hexane; dichloromethane; ethyl acetate; toluene; 1.1: Substitution / 2.1: Substitution / 3.1: Cyclization / 4.1: Hydrogenolysis / 4.2: Substitution;
DOI:10.1021/jo991578y

Reference yield:

: 96845-45-3,261911-63-1
(S)-(+)-5-methoxymethyl-2-oxotetrahydrofuran

: 261911-57-3
(5R)-1-(o-tert-butyldiphenylsiloxyphenyl)-5-(methoxymethyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 77 percent / Me₃AL / toluene; hexane / Thermolysis

2.1: Et₃N / CH₂Cl₂

3.1: t-BuOK / toluene / 20 °C

4.1: H₂ / Pd/C / ethyl acetate / 5 h

4.2: 92 percent / NaH / tetrahydrofuran / 3 h / 20 °C

With potassium tert-butylate; hydrogen; trimethylaluminum; triethylamine; palladium on activated charcoal; In hexane; dichloromethane; ethyl acetate; toluene; 1.1: Substitution / 2.1: Substitution / 3.1: Cyclization / 4.1: Hydrogenolysis / 4.2: Substitution;
DOI:10.1021/jo991578y