20012-63-9

Basic information

• Product Name: 2-BENZYLOXYANILINE
• Synonyms: 2-(benzyloxy)phenylamine;2-Benzyloxyaniline,97%;2-Aminophenyl benzyl ether;2-(Benzyloxy)benzenaMine;2-(PhenylMethoxy)benzenaMine;NSC 46882;o-(Benzyloxy)aniline;O-Benzyl-o-aMinophenol
• CAS NO: 20012-63-9
• Molecular Formula: C₁₃H₁₃NO
• Molecular Weight: 199.25
• Product Categories: Nitrogen Compounds;Building Blocks;C13;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Anilines, Aromatic Amines and Nitro Compounds;Aromatics Compounds;Aromatics;C11 to C38;Amines
• Mol File: 20012-63-9.mol
• Article Data: 29

Chemical Properties

• Melting Point: 35-39 °C(lit.)
• Boiling Point: 113°C/0.1mmHg(lit.)
• Flash Point: >230 °F
• Appearance: White to gray to brown/Crystalline Powder or Lms
• Density: 1.129 g/cm³
• Vapor Pressure: 6.02E-05mmHg at 25°C
• Refractive Index: 1.616
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly), Met
• PKA: 4.40±0.10(Predicted)
• CAS DataBase Reference: 2-BENZYLOXYANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYLOXYANILINE(20012-63-9)
• EPA Substance Registry System: 2-BENZYLOXYANILINE(20012-63-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 20012-63-9(Hazardous Substances Data)

Usage

Chemical Properties

Brown Solid

Uses

2-Benzyloxyaniline was used to investigate crystal structure of benzyloxybenzoic acids and benzyloxyanilines by X-ray powder diffraction technique. It was also used in the synthesis of 2-benzyloxyphenylhydrazine.

General Description

2-Benzyloxyaniline is an important intermediate in organic synthesis.

InChI:InChI=1/C13H13NO/c14-12-8-4-5-9-13(12)15-10-11-6-2-1-3-7-11/h1-9H,10,14H2

Upstream product

• 20012-60-6 2-(2-(benzyloxy)phenyl) isoindoline-1,3-dione 
• 95-55-6 2-amino-phenol 
• 1624-53-9 2-(benzylideneamino)phenol 
• 100-39-0 benzyl bromide 
• 100-51-6 benzyl alcohol 
• 1493-27-2 ortho-nitrofluorobenzene 
• 100-44-7 benzyl chloride 
• 1206797-33-2 ((2-azidophenoxy)methyl)benzene 
• 4560-41-2 2-benzyloxynitrobenzene 
• 34288-19-2 N-(2-(benzyloxy)phenyl)acetamide 
• 824-38-4 potassium 2-nitrophenoxide 
• 620-05-3 iodomethylbenzene 
• 824-39-5 sodium o-nitrophenate 
• 86255-27-8 silver(I) 2-nitrophenoxide 

Downstream Products

• 92425-88-2 chloro-acetic acid-(2-benzyloxy-anilide) 
• 19966-03-1 Benzyl-o-(p-toluolsulfonyl)aminophenylether 
• 22486-40-4 N-(2-Benzyloxy-phenyl)-N'-(2-methoxy-phenyl)-oxalamide 
• 85805-36-3 2-Benzyloxyphenylaminomalonsaeurediethylester 
• 136582-00-8 N-(2-benzyloxyphenyl)-β-alanine 
• 26774-07-2 diethyl <<2-(benzyloxy)anilino>methylene>malonate 
• 261911-55-1 (4S)-N-(o-(benzyloxy)phenyl)-4-hydroxy-5-methoxypentanamide 
• 100-51-6 benzyl alcohol 
• 179625-75-3 ethyl 3-[2-(benzyloxy)anilino]-2-butenoate 
• 39082-29-6 2-benzyloxy-benzenesulfonic acid amide 
• 1024010-15-8 N-(2-(benzyloxy)phenyl)-3-fluoroisonicotinamide 
• 943630-01-1 5-{[(2-benzyloxy)phenylimino]methyl}-2,2-dimethyl-[1,3]-dioxane-4,6-dione 
• 86652-64-4 1-benzyloxy-2-isocyanobenzene 
• 1286784-65-3 C₄₂H₅₂N₄O₅ 

Relevant articles and documents

First Total Synthesis of the Cytotoxic Carbazole Alkaloid Excavatine-A and Regioselective Annulation to Pyrano[2,3-a]carbazoles and [1,4]Oxazepino[2,3,4-jk]carbazoles

We describe the first total synthesis of the cytotoxic carbazole alkaloid excavatine-A. The carbazole framework was constructed through double C–H bond activation of a diarylamine by using our palladium(II)-catalyzed oxidative cyclization. Treatment of th

Synthesis of aspidodispermine via pericyclic framework reconstruction

A divergent approach to the pyrroloquinoline scaffold as present in the class of Aspidosperma alkaloids was developed. As a case study, abundant and renewable nicotinic acid was transformed via pericyclic framework reconstruction into aspidodispermine, a unique member of pyrroloquinoline alkaloids. The sequence comprises a [2 + 2]-photocycloaddition, a Ramberg-B?cklund contraction, and a strain-promoted formal electrocyclic rearrangement of a bicyclo[2.2.0]hexene and is potentially extendable to pyrroloindole scaffolds as present in the ibophyllidine alkaloids.

IMPROVED PROCESS FOR THE PREPARATION OF [3R,5R]-2-FLUOROPHENYL-β,δ- DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(2-HYDROXYPHENYLAMINO)- CARBONYL]-1H-PYRROLE-1-HEPTANOIC ACID, SODIUM SALT

The present invention relates to an improved process for the preparation of [3R,5R]-2-fluorophenyl-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(2-hydroxyphenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid sodium salt compound of formula- 1 represented by the following structural formula: