3-<2-(tert-butoxycarbonyl)-1-ethyl-3-(2-hydroxyphenyl)-3-oxopropyl>benzoic acid tert-butyl ester

Base Information

Chemical Name:3-<2-(tert-butoxycarbonyl)-1-ethyl-3-(2-hydroxyphenyl)-3-oxopropyl>benzoic acid tert-butyl ester
CAS No.:166186-73-8
Molecular Formula:C₂₇H₃₄O₆
Molecular Weight:454.563
Hs Code.:

Synonyms:3-<2-(tert-butoxycarbonyl)-1-ethyl-3-(2-hydroxyphenyl)-3-oxopropyl>benzoic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-<2-(tert-butoxycarbonyl)-1-ethyl-3-(2-hydroxyphenyl)-3-oxopropyl>benzoic acid tert-butyl ester

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Technology Process of 3-<2-(tert-butoxycarbonyl)-1-ethyl-3-(2-hydroxyphenyl)-3-oxopropyl>benzoic acid tert-butyl ester

There total 5 articles about 3-<2-(tert-butoxycarbonyl)-1-ethyl-3-(2-hydroxyphenyl)-3-oxopropyl>benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50916-34-2
3-propionylbenzonitrile

: 166186-73-8
3-<2-(tert-butoxycarbonyl)-1-ethyl-3-(2-hydroxyphenyl)-3-oxopropyl>benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) benzene, a) 5 deg C, 15 min, b) RT, 1.5 h, 2.) benzene, from 5 deg C to RT, overnight

2: 93 percent / H₂ / 5percent Pd/C / ethyl acetate / 2585.7 Torr

3: 84 percent / 30percent aq. potassium hydroxide / ethanol / 70 °C

4: 75 percent / benzene / 2 h / Heating

5: 1.) diisopropylamine, n-butyllithium / 1.) THF, hexane, -78 deg C, 45 min, 2.) THF, hexane, from -78 deg C to RT, overnight

With potassium hydroxide; n-butyllithium; hydrogen; sodium hydride; diisopropylamine; palladium on activated charcoal; In ethanol; ethyl acetate; benzene;
DOI:10.1021/jm00018a023

Reference yield:

: 166186-94-3
3-(3-cyanophenyl)pent-2-enoic acid tert-butyl ester

: 166186-73-8
3-<2-(tert-butoxycarbonyl)-1-ethyl-3-(2-hydroxyphenyl)-3-oxopropyl>benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / H₂ / 5percent Pd/C / ethyl acetate / 2585.7 Torr

2: 84 percent / 30percent aq. potassium hydroxide / ethanol / 70 °C

3: 75 percent / benzene / 2 h / Heating

4: 1.) diisopropylamine, n-butyllithium / 1.) THF, hexane, -78 deg C, 45 min, 2.) THF, hexane, from -78 deg C to RT, overnight

With potassium hydroxide; n-butyllithium; hydrogen; diisopropylamine; palladium on activated charcoal; In ethanol; ethyl acetate; benzene;
DOI:10.1021/jm00018a023

Reference yield:

: 166186-96-5
3-<1-(carboxymethyl)propyl>benzoic acid

: 166186-73-8
3-<2-(tert-butoxycarbonyl)-1-ethyl-3-(2-hydroxyphenyl)-3-oxopropyl>benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / benzene / 2 h / Heating

2: 1.) diisopropylamine, n-butyllithium / 1.) THF, hexane, -78 deg C, 45 min, 2.) THF, hexane, from -78 deg C to RT, overnight

With n-butyllithium; diisopropylamine; In benzene;
DOI:10.1021/jm00018a023