50916-34-2

Usage

Uses

Used in Pharmaceutical Industry:
Benzonitrile, 3-(1-oxopropyl)is used as an intermediate compound for the synthesis of pyrimidinediones, which are apelin receptor agonists. These agonists play a crucial role in various physiological processes, including blood pressure regulation, body weight control, and energy homeostasis. The development of apelin receptor agonists has significant potential in the treatment of conditions such as hypertension, heart failure, and obesity.

Upstream product

• 34841-35-5 3'-chloro-propiophenone 
• 19829-31-3 1-(3-bromophenyl)-1-propanone 
• 17408-16-1 3'-nitropropiophenone 
• 6952-59-6 3-cyanobromobenzene 
• 79-03-8 propionyl chloride 
• 1197-05-3 1-(3-amino-phenyl)-propan-1-one 
• 151-50-8 potassium cyanide 
• 544-92-3 copper(I) cyanide 

Downstream Products

• 74380-71-5 3-hydroxycarbonyl-propiophenone 
• 1415829-33-2 C₁₂H₉N₃O₂ 
• 1212967-40-2 (S)-3-(1-aminopropyl)benzonitrile 
• 1440663-52-4 (E)-3-(3-(5-methylthiophen-2-yl)acryloyl)benzonitrile 
• 1372393-76-4 C₁₆H₁₀N₂O₃ 
• 86042-92-4 3-((2R,3S)-2,3-Dimethyl-6-oxo-tetrahydro-pyran-2-yl)-benzonitrile 
• 86042-92-4 3-((2R,3R)-2,3-Dimethyl-6-oxo-tetrahydro-pyran-2-yl)-benzonitrile 
• 154320-61-3 3-benzoyl-α-chloro-propiophenone 
• 72563-47-4 3-propionylbenzoyl chloride 
• 66952-39-4 1-(3-benzoylphenyl)propan-1-one 
• 166186-73-8 3-<2-(tert-butoxycarbonyl)-1-ethyl-3-(2-hydroxyphenyl)-3-oxopropyl>benzoic acid tert-butyl ester 
• 166186-74-9 3-<1-(4-hydroxy-2-oxo-2H-chromen-3-yl)propyl>benzoic acid 
• 166186-72-7 3-<1-<(tert-butoxycarbonyl)methyl>propyl>benzoic acid tert-butyl ester 
• 166186-71-6 3-(3-cyanophenyl)pentanoic acid tert-butyl ester 

Relevant academic research and scientific papers

APELIN RECEPTOR AGONISTS AND METHODS OF USE

The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.

A straightforward and versatile protocol for the direct conversion of benzylic azides to ketones and aldehydes

The synthesis of carbonyl compounds from benzylic azides through benzylideneamides is described for the first time. NaH-mediated activation of benzyl azides allows a rapid water-promoted oxidation under a facile protocol with good yields.

A mild and efficient palladium-catalyzed cyanation of aryl chlorides with K4[Fe(CN)6]

An efficient palladium-catalyzed cyanation of aryl chlorides is established. In the presence of a highly effective Pd/CM-phos catalyst, cyanation of aryl chlorides proceeds at 70 °C in general, which is the mildest reaction temperature achieved so far for this process. Common functional groups such as keto, aldehyde, ester, nitrile and-NH2, and heterocyclic coupling partners including N-H indoles are well tolerated. Moreover, a sterically hindered nonactivated ortho,ortho-disubstituted electrophile is shown to be a feasible coupling partner in cyanation.

PIPERIDINE-AMIDE DERIVATIVES

The invention is concerned with novel piperidine-amide derivatives of formula (I) wherein R1, R2, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These comp

N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action

The synthesis of a series of N-aminoimidazoles (NAIMs) with an uncommon spectrum of antiretroviral activity is described. From a group of 60 closely related molecules, we were able to subdivide the molecules in different groups based on their anti-HIV and anti-SIV activity in vitro: (i) molecules acting on a new, immediate postintegration step, (ii) molecules acting on both postintegration and HIV-1 reverse transcriptase (RT) as NNRTI, and (iii) molecules that mainly act at the HIV-1 RT according to an NNRTI-type mode of action.

Preparation and reactivity of functionalized aryl and alkenylmanganese halides

Various functionalized aryl and alkenyl manganese halides have been prepared from the corresponding aryl and alkenylhalides according to a one-pot procedure: lithium-halogen exchange at low temperature then Li-Mn transmetallation.

Photochemical Rearrangement of α-Chloro-Propiophenones to α-Arylpropanoic Acids: Studies on Chirality Transfer and Synthesis of (S)-(+)-Ibuprofen and (S)-(+)-Ketoprofen

A new single-step efficient photochemical approach for α-arylpropanoic acids (4) from α-chloro-propiophenones (5) is described.It involves carbonyl triplet excited state directed 1,2-aryl migration of the aryl group which has been found to be highly dependent upon the nature of the aryl substituent.The mode of the rearrangement is probed by the study of the photobehaviour of a set of optically active α-chloro-propiophenones.The results suggest that the nature of the carbonyl triplets (n, ?*/ ?, ?*) plays an important role in the chirality transfer.This method finds application in the synthesis of optically active ibuprofen (4e) and ketoprofen (26), though in moderate optical yields.

3' Cyanophenylalkanolamines: a contribution to the search for selective β adrenomimetic compounds

Some derivatives of 1 (3' cyanophenyl) 2 aminoethanol have been synthesized in which OH is substituted at the nucleus, methyl or ethyl at the α carbon atom and isopropyl or t butyl at the nitrogen atom. The pharmacological research has shown that by combi