ethyl 8-(p-chlorophenylsulfonamido)-3-[4-(pyridin-3-yl)-butyl]-octanoate

Base Information

Chemical Name:ethyl 8-(p-chlorophenylsulfonamido)-3-[4-(pyridin-3-yl)-butyl]-octanoate
CAS No.:134162-96-2
Molecular Formula:C₂₅H₃₅ClN₂O₄S
Molecular Weight:495.083
Hs Code.:

Synonyms:ethyl 8-(p-chlorophenylsulfonamido)-3-[4-(pyridin-3-yl)-butyl]-octanoate

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Chemical Property of ethyl 8-(p-chlorophenylsulfonamido)-3-[4-(pyridin-3-yl)-butyl]-octanoate

Chemical Property:

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Technology Process of ethyl 8-(p-chlorophenylsulfonamido)-3-[4-(pyridin-3-yl)-butyl]-octanoate

There total 8 articles about ethyl 8-(p-chlorophenylsulfonamido)-3-[4-(pyridin-3-yl)-butyl]-octanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 134163-03-4
ethyl 8-amino-3-[4-(pyridin-3-yl)-butyl]-octanoate

: 134162-96-2
ethyl 8-(p-chlorophenylsulfonamido)-3-[4-(pyridin-3-yl)-butyl]-octanoate

Guidance literature:: With triethylamine; In dichloromethane; Ambient temperature;
DOI:10.1021/jm00101a014

Reference yield:

: 30414-57-4
methyl 3-oxohept-6-enoate

: 134162-96-2
ethyl 8-(p-chlorophenylsulfonamido)-3-[4-(pyridin-3-yl)-butyl]-octanoate

Guidance literature:: Multi-step reaction with 8 steps

1: Et₃N, Pd(OAc)2, tri-o-tolylphosphine / acetonitrile / 20 h / Heating

2: 1.) NaH / 1.) DMF, 25 deg C, 0.5 h, 2.) DMF, RT, 18 h

3: aq. NaCl / dimethylsulfoxide / 14 h / Heating

4: 1.) NaH / 1.) THF, 2.) THF

5: H₂ / Pd/C

6: H₂ / Raney Ni

7: H₂ / Pd/C / 100 h / 2327.2 Torr

8: Et₃N / CH₂Cl₂ / Ambient temperature

With palladium diacetate; hydrogen; sodium hydride; triethylamine; tris-(o-tolyl)phosphine; sodium chloride; palladium on activated charcoal; nickel; In dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm00101a014

Reference yield:

: 10-(3-pyridinyl)-6-oxo-9-decenenitrile

: 134162-96-2
ethyl 8-(p-chlorophenylsulfonamido)-3-[4-(pyridin-3-yl)-butyl]-octanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) THF, 2.) THF

2: H₂ / Pd/C

3: H₂ / Raney Ni

4: H₂ / Pd/C / 100 h / 2327.2 Torr

5: Et₃N / CH₂Cl₂ / Ambient temperature

With hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; nickel; In dichloromethane;
DOI:10.1021/jm00101a014