RE₁₆₄

Base Information

Chemical Name:RE₁₆₄
CAS No.:1607800-35-0
Molecular Formula:C₃₁H₃₂ClNO₅
Molecular Weight:534.052
Hs Code.:

Synonyms:RE₁₆₄

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Chemical Property of RE₁₆₄

Chemical Property:

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Technology Process of RE₁₆₄

There total 12 articles about RE₁₆₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1607800-32-7
C₄₇H₅₀ClNO₅Si

: 1607800-35-0
RE₁₆₄

Guidance literature:: With tris(dimethylamino)sulfonium trimethylsilyldifluoride; In N,N-dimethyl-formamide; at 0 ℃; for 29h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.03.012

Reference yield:

: 1929-29-9
3-(4-methoxyphenyl)propanoic acid

: 1607800-35-0
RE₁₆₄

Guidance literature:: Multi-step reaction with 12 steps

1.1: sulfuric acid / 3.5 h / Reflux; Inert atmosphere

2.1: diisobutylaluminium hydride / tetrahydrofuran / 2.5 h / -78 °C / Inert atmosphere

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.33 h / 20 °C / Inert atmosphere

4.1: toluene / 0.33 h / Inert atmosphere; Reflux

5.1: hydrogen; palladium on activated charcoal / ethanol / 10 h / 20 °C / Inert atmosphere

6.1: hydrogen bromide / acetic acid / 3 h / Inert atmosphere; Reflux

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 8 h / 0 - 20 °C / Inert atmosphere

8.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C / Inert atmosphere

9.1: Lawessons reagent / tetrahydrofuran / 0.33 h / Inert atmosphere; Reflux

10.1: potassium carbonate / acetone / 7 h / 20 °C / Inert atmosphere; Enzymatic reaction

11.1: dichloromethane / 30 h / 20 °C / Inert atmosphere; Molecular sieve

12.1: tris(dimethylamino)sulfonium trimethylsilyldifluoride / N,N-dimethyl-formamide / 29 h / 0 °C / Inert atmosphere

With Lawessons reagent; dmap; oxalyl dichloride; sulfuric acid; palladium on activated charcoal; tris(dimethylamino)sulfonium trimethylsilyldifluoride; hydrogen bromide; hydrogen; sodium hydride; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone; toluene; 4.1: |Wittig Olefination;
DOI:10.1016/j.bmc.2014.03.012

Reference yield:

: 15823-04-8
methyl 3-(4-methoxyphenyl)propionate

: 1607800-35-0
RE₁₆₄

Guidance literature:: Multi-step reaction with 11 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran / 2.5 h / -78 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.33 h / 20 °C / Inert atmosphere

3.1: toluene / 0.33 h / Inert atmosphere; Reflux

4.1: hydrogen; palladium on activated charcoal / ethanol / 10 h / 20 °C / Inert atmosphere

5.1: hydrogen bromide / acetic acid / 3 h / Inert atmosphere; Reflux

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 8 h / 0 - 20 °C / Inert atmosphere

7.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C / Inert atmosphere

8.1: Lawessons reagent / tetrahydrofuran / 0.33 h / Inert atmosphere; Reflux

9.1: potassium carbonate / acetone / 7 h / 20 °C / Inert atmosphere; Enzymatic reaction

10.1: dichloromethane / 30 h / 20 °C / Inert atmosphere; Molecular sieve

11.1: tris(dimethylamino)sulfonium trimethylsilyldifluoride / N,N-dimethyl-formamide / 29 h / 0 °C / Inert atmosphere

With Lawessons reagent; dmap; oxalyl dichloride; palladium on activated charcoal; tris(dimethylamino)sulfonium trimethylsilyldifluoride; hydrogen bromide; hydrogen; sodium hydride; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone; toluene; 3.1: |Wittig Olefination;
DOI:10.1016/j.bmc.2014.03.012