15823-04-8

Basic information

• Product Name: METHYL 3-(4-METHOXYPHENYL)PROPIONATE
• Synonyms: 4-Methoxyhydrocinnamic acid methyl ester;Benzenepropanoic acid, 4-methoxy-, methyl ester;Hydrocinnamic acid, p-methoxy-, methyl ester;Methyl 3-(4-methoxyphenyl)propanoate;Methyl 3-(p-methoxyphenyl)-propionate;METHYL P-METHOXYHYDROCINNAMATE;METHYL 3-(4-METHOXYPHENYL)PROPIONATE;METHYL 4-METHOXYPHENYLPROPIONATE
• CAS NO: 15823-04-8
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.23
• Product Categories: Aromatic Esters
• Mol File: 15823-04-8.mol
• Article Data: 60

Chemical Properties

• Melting Point: 37-41 °C
• Boiling Point: 120 °C
• Flash Point: 110 °C
• Appearance: /
• Density: 1.062 g/cm³
• Vapor Pressure: 0.00553mmHg at 25°C
• Refractive Index: 1.497
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL 3-(4-METHOXYPHENYL)PROPIONATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-(4-METHOXYPHENYL)PROPIONATE(15823-04-8)
• EPA Substance Registry System: METHYL 3-(4-METHOXYPHENYL)PROPIONATE(15823-04-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 15823-04-8(Hazardous Substances Data)

Usage

General Description

METHYL 3-(4-METHOXYPHENYL)PROPIONATE is a chemical compound with the molecular formula C12H14O3. It is commonly used as a flavor and fragrance agent in various products, including perfumes, cosmetics, and food. METHYL 3-(4-METHOXYPHENYL)PROPIONATE is derived from the esterification of 4-methoxyphenylacetic acid with methanol. It has a sweet, floral, and fruity aroma, making it a popular choice for adding a pleasant scent to consumer goods. Additionally, it is known for its ability to enhance the overall flavor profile of food and beverages. However, it is important to handle this chemical with care, as it can potentially cause skin and eye irritation if proper precautions are not taken.

InChI:InChI=1/C11H14O3/c1-13-10-6-3-9(4-7-10)5-8-11(12)14-2/h3-4,6-7H,5,8H2,1-2H3

Upstream product

• 501-97-3 4-hydroxyphenylpropionic acid 
• 74-88-4 methyl iodide 
• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 292638-85-8 acrylic acid methyl ester 
• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 
• 67-56-1 methanol 
• 106-41-2 4-bromo-phenol 
• 696-62-8 para-iodoanisole 
• 540-38-5 p-Iodophenol 
• 591-31-1 3-methoxy-benzaldehyde 
• 201230-82-2 carbon monoxide 
• 77525-91-8 1-methoxy-4-(1-methoxy-ethyl)-benzene 

Downstream Products

• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 
• 25413-27-8 3-(4-methoxy-phenyl)propionamide 
• 121670-33-5 3-(4-methoxyphenyl)propionic acid hydrazide 
• 91671-18-0 methyl 2-<4-(1-hydroxy-1,3-dimethyl-3-butenyl)phenyl>-propionate 
• 77092-59-2 2-(p-methoxyphenylpropionoyloxy)(a)-4-(3'-MEMoxy-4'-methoxyphenyl)(e)-trans-quinolizidine 
• 128257-37-4 1-(4-Methoxy-bicyclo[4.2.0]octa-1⁽⁶⁾,2,4-trien-7-yl)-3-(4-methoxy-phenyl)-propan-1-one 
• 128257-29-4 2-Hydroxy-6-methoxy-2-[2-(4-methoxy-phenyl)-ethyl]-indan-1-one 
• 88537-37-5 3,5-bis(4-methoxyphenylethyl)isoxazole 
• 5406-18-8 3-(p-methoxyphenyl)-1-propanol 
• 117286-83-6 methyl 3-(4-methoxybenzoyl)-4-methoxyphenylpropionate 
• 144340-74-9 1-chloro-3-(4-methoxybenzyl)-2-propanone 
• 116254-64-9 dimethyl (4-(4-methoxyphenyl)-2-oxobutyl)phosphonate 
• 14305-29-4 3-hydroxy-1-(4-methoxyphenyl)-3-methylbutane 
• 71480-99-4 2,2,3-Trichloro-3-(4-methoxy-phenyl)-propionic acid (2S,4S,9aS)-4-(3,4-dimethoxy-phenyl)-octahydro-quinolizin-2-yl ester 

Relevant articles and documents

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Manganese-catalyzed homogeneous hydrogenation of ketones and conjugate reduction of α,β-unsaturated carboxylic acid derivatives: A chemoselective, robust, and phosphine-free in situ-protocol

We communicate a user-friendly and glove-box-free catalytic protocol for the manganese-catalyzed hydrogenation of ketones and conjugated C[dbnd]C[sbnd]bonds of esters and nitriles. The respective catalyst is readily assembled in situ from the privileged [Mn(CO)5Br] precursor and cheap 2-picolylamine. The catalytic transformations were performed in the presence of t-BuOK whereby the corresponding hydrogenation products were obtained in good to excellent yields. The described system offers a brisk and atom-efficient access to both secondary alcohols and saturated esters avoiding the use of oxygen-sensitive and expensive phosphine-based ligands.

Efficient palladium-catalyzed synthesis of 2-aryl propionic acids

A flexible two-step, one-pot procedure was developed to synthesize 2-aryl propionic acids including the anti-inflammatory drugs naproxen and flurbiprofen. Optimal results were obtained in the presence of the novel ligand neoisopinocampheyldiphenylphosphine (NISPCPP) (9) which enabled the efficient sequential palladium-catalyzed Heck coupling of aryl bromides with ethylene and hydroxycarbonylation of the resulting styrenes to 2-aryl propionic acids. This cascade transformation leads with high regioselectivity to the desired products in good yields and avoids the need for additional purification steps.