Technology Process of 3-(2-hydroxy-6-oxo-1-cyclohexenecarbonyl)-1-methylquinolin-2(1H)-one
There total 7 articles about 3-(2-hydroxy-6-oxo-1-cyclohexenecarbonyl)-1-methylquinolin-2(1H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-oxo-1-cyclohexenyl 1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate;
With
triethylamine; 2-hydroxy-2-methylpropanenitrile;
In
acetonitrile;
at 20 ℃;
for 24h;
With
citric acid;
In
water;
pH=3 - 4;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: acetic acid / 20 - 80 °C
1.2: 5 h / 80 - 100 °C
2.1: sodium hydride / N,N-dimethyl-formamide; 1,2-dimethoxyethane; mineral oil / 0.25 h / 20 °C / Inert atmosphere
2.2: 0.25 h / 20 °C
2.3: 3 h / 20 - 60 °C
3.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 24 h / 20 °C
4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 40 °C
5.1: triethylamine / acetonitrile / 20 °C / Cooling with ice
6.1: 2-hydroxy-2-methylpropanenitrile; triethylamine / acetonitrile / 24 h / 20 °C
6.2: pH 3 - 4
With
oxalyl dichloride; lithium hydroxide monohydrate; water; sodium hydride; acetic acid; triethylamine; 2-hydroxy-2-methylpropanenitrile;
N,N-dimethyl-formamide;
In
1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: acetic anhydride; sodium hydrogencarbonate / 20 - 100 °C
2.1: acetic acid / 20 - 80 °C
2.2: 5 h / 80 - 100 °C
3.1: sodium hydride / N,N-dimethyl-formamide; 1,2-dimethoxyethane; mineral oil / 0.25 h / 20 °C / Inert atmosphere
3.2: 0.25 h / 20 °C
3.3: 3 h / 20 - 60 °C
4.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 24 h / 20 °C
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 40 °C
6.1: triethylamine / acetonitrile / 20 °C / Cooling with ice
7.1: 2-hydroxy-2-methylpropanenitrile; triethylamine / acetonitrile / 24 h / 20 °C
7.2: pH 3 - 4
With
oxalyl dichloride; lithium hydroxide monohydrate; water; acetic anhydride; sodium hydride; sodium hydrogencarbonate; acetic acid; triethylamine; 2-hydroxy-2-methylpropanenitrile;
N,N-dimethyl-formamide;
In
1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
