17422-56-9 Usage
Description
Diethyl 2-[(2-nitrophenyl)methylidene]propanedioate, also known as 2-nitrocinnamaldehyde diethyl acetal, is a yellow solid chemical compound with a molecular formula of C15H17NO5 and a molar mass of 287.30 g/mol. It is characterized by its aromatic and aliphatic properties, making it a versatile compound in organic synthesis.
Uses
Used in Organic Synthesis:
Diethyl 2-[(2-nitrophenyl)methylidene]propanedioate is used as a reagent in organic reactions for the production of various aromatic and aliphatic derivatives. Its unique properties allow for the creation of a wide range of chemical compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, diethyl 2-[(2-nitrophenyl)methylidene]propanedioate is utilized in the manufacturing of various pharmaceuticals. Its versatility and reactivity make it a valuable component in the development of new drugs and medicinal compounds.
Used in Dye Industry:
Diethyl 2-[(2-nitrophenyl)methylidene]propanedioate is also employed in the dye industry for the production of different types of dyes. Its chemical properties contribute to the color and stability of the dyes, making it an essential component in this field.
Used in Agrochemical Industry:
In the agrochemical industry, diethyl 2-[(2-nitrophenyl)methylidene]propanedioate plays a significant role in the development of various agrochemicals. Its use in this industry helps improve the effectiveness and efficiency of agricultural products.
Overall, diethyl 2-[(2-nitrophenyl)methylidene]propanedioate is a crucial compound in the advancement of chemical and pharmaceutical industries, with its applications spanning across various fields, including organic synthesis, pharmaceuticals, dyes, and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 17422-56-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,4,2 and 2 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 17422-56:
(7*1)+(6*7)+(5*4)+(4*2)+(3*2)+(2*5)+(1*6)=99
99 % 10 = 9
So 17422-56-9 is a valid CAS Registry Number.
InChI:InChI=1/C14H15NO6/c1-3-20-13(16)11(14(17)21-4-2)9-10-7-5-6-8-12(10)15(18)19/h5-9H,3-4H2,1-2H3
17422-56-9Relevant articles and documents
Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3 H-1,2,4-triazol-3-one, by Fragment-Based Drug Design
Sabat, Mark,Dougan, Douglas R.,Knight, Beverly,Lawson, J. David,Scorah, Nicholas,Smith, Christopher R.,Taylor, Ewan R.,Vu, Phong,Wyrick, Corey,Wang, Haixia,Balakrishna, Deepika,Hixon, Mark,Madakamutil, Loui,McConn, Donavon
supporting information, p. 12893 - 12902 (2021/09/13)
This publication details the successful use of FBDD (fragment-based drug discovery) principles in the invention of a novel covalent Bruton's tyrosine kinase inhibitor, which ultimately became the Takeda Pharmaceuticals clinical candidate TAK-020. Describe
Solvent-Free FeCl3-Assisted Electrophilic Fluorine-Catalyzed Knoevenagel Condensation to Yield α,β-Unsaturated Dicarbonyl Compounds and Coumarins
Yang, Lu,Zhu, Jiang,Xie, Fukai,Peng, Xiaoshi,Lin, Bin,Liu, Yongxiang,Cheng, Maosheng
, p. 1053 - 1060 (2019/09/06)
A highly environmentally friendly procedure was developed for the Knoevenagel condensation of aromatic aldehydes with diethyl malonate in the presence of FeCl3 and N-fluorobenzenesulfonimide as a source of electrophilic fluorine under solvent-free conditions. The scope of the reaction was explored using commercially available substrates. The reaction with substituted salicylaldehydes afforded the corresponding coumarin derivatives which attract interest due to their potential medicinal importance.
Visible-Light-Driven Intermolecular [2+2] Cycloadditions between Coumarin-3-Carboxylates and Acrylamide Analogs
Liu, Qiang,Zhu, Fu-Ping,Jin, Xiao-Ling,Wang, Xiao-Ju,Chen, Han,Wu, Li-Zhu
supporting information, p. 10326 - 10329 (2015/07/07)
This paper reports a room temperature visible-light-driven protocol for the intermolecular [2+2] cycloadditions between coumarin-3-carboxylates and acrylamides analogs by an energy-transfer process. Using an iridium complex FIrPic as a photosensitizer and a 3W blue LED as a light source, an array of cyclobutabenzocypyranones were prepared in moderate to excellent yields.