(S)-1-((S)-3,4-Dimethyl-cyclohex-3-enecarbonyl)-pyrrolidine-2-carboxylic acid benzyl ester

Base Information

• Chemical Name: (S)-1-((S)-3,4-Dimethyl-cyclohex-3-enecarbonyl)-pyrrolidine-2-carboxylic acid benzyl ester
• CAS No.: 117775-73-2
• Molecular Formula: C₂₁H₂₇NO₃
• Molecular Weight: 341.45
• Mol file: 117775-73-2.mol

Synonyms:(S)-1-((S)-3,4-Dimethyl-cyclohex-3-enecarbonyl)-pyrrolidine-2-carboxylic acid benzyl ester

Chemical Property of (S)-1-((S)-3,4-Dimethyl-cyclohex-3-enecarbonyl)-pyrrolidine-2-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-((S)-3,4-Dimethyl-cyclohex-3-enecarbonyl)-pyrrolidine-2-carboxylic acid benzyl ester

There total 2 articles about (S)-1-((S)-3,4-Dimethyl-cyclohex-3-enecarbonyl)-pyrrolidine-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-acryloyl-(S)-proline benzyl ester (117775-65-2) + 2,3-dimethyl-buta-1,3-diene (513-81-5) → N-<((4R)-1,2-dimethylcyclohex-1-en-4-yl)carbonyl>-(S)-proline benzyl ester (117775-72-1) + (S)-1-((S)-3,4-Dimethyl-cyclohex-3-enecarbonyl)-pyrrolidine-2-carboxylic acid benzyl ester (117775-73-2)

Guidance literature:

titanium tetrachloride; In dichloromethane; at 20 ℃; Yield given. Yields of byproduct given;

Reference yield:

benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride (16652-71-4) → (S)-1-((S)-3,4-Dimethyl-cyclohex-3-enecarbonyl)-pyrrolidine-2-carboxylic acid benzyl ester (117775-73-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 14 h / Ambient temperature

2: TiCl₄ / CH₂Cl₂ / 5 h / 20 °C

With dmap; titanium tetrachloride; triethylamine; In dichloromethane;

DOI:10.1021/jo00261a034

upstream raw materials:

N-acryloyl-(S)-proline benzyl ester

2,3-dimethyl-buta-1,3-diene

benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride