3-fluoro-3-(dimethylphenylsilyl)-1-(p-toluenesulfonyl)-1,4-dihydroquinoline

Base Information

Chemical Name:3-fluoro-3-(dimethylphenylsilyl)-1-(p-toluenesulfonyl)-1,4-dihydroquinoline
CAS No.:899437-08-2
Molecular Formula:C₂₄H₂₄FNO₂SSi
Molecular Weight:437.61
Hs Code.:

Synonyms:3-fluoro-3-(dimethylphenylsilyl)-1-(p-toluenesulfonyl)-1,4-dihydroquinoline

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Chemical Property of 3-fluoro-3-(dimethylphenylsilyl)-1-(p-toluenesulfonyl)-1,4-dihydroquinoline

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Technology Process of 3-fluoro-3-(dimethylphenylsilyl)-1-(p-toluenesulfonyl)-1,4-dihydroquinoline

There total 6 articles about 3-fluoro-3-(dimethylphenylsilyl)-1-(p-toluenesulfonyl)-1,4-dihydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 899437-07-1
N-{o-[3,3-difluoro-2-(dimethylphenylsilyl)prop-2-en-1-yl]phenyl}-p-toluenesulfonamide

: 899437-08-2
3-fluoro-3-(dimethylphenylsilyl)-1-(p-toluenesulfonyl)-1,4-dihydroquinoline

Guidance literature:: N-{o-[3,3-difluoro-2-(dimethylphenylsilyl)prop-2-en-1-yl]phenyl}-p-toluenesulfonamide; With Trimethyl borate; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 5h;

With triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 3h;
DOI:10.1055/s-2006-926458

Reference yield: 53.0%

: 899437-07-1
N-{o-[3,3-difluoro-2-(dimethylphenylsilyl)prop-2-en-1-yl]phenyl}-p-toluenesulfonamide

: 2-fluoro-1-(p-toluenesulfonyl)-1,4-dihydroquinoline

: 3-(dimethylphenylsilyl)-2-fluoroquinoline

: N-[2-(3,3-difluoroallyl)phenyl]-p-toluenesulfonamide

: 899437-08-2
3-fluoro-3-(dimethylphenylsilyl)-1-(p-toluenesulfonyl)-1,4-dihydroquinoline

Guidance literature:: N-{o-[3,3-difluoro-2-(dimethylphenylsilyl)prop-2-en-1-yl]phenyl}-p-toluenesulfonamide; With triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 5h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 80 ℃; for 1h;
DOI:10.1055/s-2006-926458

Reference yield:

: 899437-05-9
3,3-difluoro-[o-(2-dimethylphenylsilyl)prop-2-en-1-yl]aniline

: 899437-08-2
3-fluoro-3-(dimethylphenylsilyl)-1-(p-toluenesulfonyl)-1,4-dihydroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: 94 percent / pyridine / 10 h / 20 °C

2.1: triethylamine / dimethylformamide / 5 h / 80 °C

2.2: 9 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 1 h / 80 °C

With pyridine; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1055/s-2006-926458