N-{o-[3,3-difluoro-2-(dimethylphenylsilyl)prop-2-en-1-yl]phenyl}-p-toluenesulfonamide

Base Information

Chemical Name:N-{o-[3,3-difluoro-2-(dimethylphenylsilyl)prop-2-en-1-yl]phenyl}-p-toluenesulfonamide
CAS No.:899437-07-1
Molecular Formula:C₂₄H₂₅F₂NO₂SSi
Molecular Weight:457.616
Hs Code.:

Synonyms:N-{o-[3,3-difluoro-2-(dimethylphenylsilyl)prop-2-en-1-yl]phenyl}-p-toluenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{o-[3,3-difluoro-2-(dimethylphenylsilyl)prop-2-en-1-yl]phenyl}-p-toluenesulfonamide

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Technology Process of N-{o-[3,3-difluoro-2-(dimethylphenylsilyl)prop-2-en-1-yl]phenyl}-p-toluenesulfonamide

There total 4 articles about N-{o-[3,3-difluoro-2-(dimethylphenylsilyl)prop-2-en-1-yl]phenyl}-p-toluenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 899437-05-9
3,3-difluoro-[o-(2-dimethylphenylsilyl)prop-2-en-1-yl]aniline

: 98-59-9
p-toluenesulfonyl chloride

: 899437-07-1
N-{o-[3,3-difluoro-2-(dimethylphenylsilyl)prop-2-en-1-yl]phenyl}-p-toluenesulfonamide

Guidance literature:: With pyridine; at 20 ℃; for 10h;
DOI:10.1055/s-2006-926458

Reference yield:

: tert-butyl N-{o-[3,3-difluoro-2-(dimethylphenylsilyl)prop-2-en-1-yl]phenyl}carbamate

: 899437-07-1
N-{o-[3,3-difluoro-2-(dimethylphenylsilyl)prop-2-en-1-yl]phenyl}-p-toluenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / trimethylsilyl iodide / CHCl₃ / 3 h / 0 - 20 °C

2: 94 percent / pyridine / 10 h / 20 °C

With pyridine; trimethylsilyl iodide; In chloroform;
DOI:10.1055/s-2006-926458

Reference yield:

: 3422-01-3
tert-butyl phenylcarbamate

: 899437-07-1
N-{o-[3,3-difluoro-2-(dimethylphenylsilyl)prop-2-en-1-yl]phenyl}-p-toluenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tert-butyllithium; tetrahydropyran / pentane / 1 h / 20 °C

1.2: 34 percent / pentane / 20 h / 20 °C

2.1: 54 percent / trimethylsilyl iodide / CHCl₃ / 3 h / 0 - 20 °C

3.1: 94 percent / pyridine / 10 h / 20 °C

With TETRAHYDROPYRANE; pyridine; trimethylsilyl iodide; tert.-butyl lithium; In chloroform; pentane;
DOI:10.1055/s-2006-926458