(S)-11-cyclohexyl-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano-[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione

Base Information

• Chemical Name: (S)-11-cyclohexyl-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano-[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione
• CAS No.: 78287-30-6
• Molecular Formula: C₂₆H₂₆N₂O₄
• Molecular Weight: 430.503
• Mol file: 78287-30-6.mol

Synonyms:(S)-11-cyclohexyl-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano-[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione

Chemical Property of (S)-11-cyclohexyl-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano-[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-11-cyclohexyl-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano-[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione

There total 7 articles about (S)-11-cyclohexyl-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano-[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

cyclohexylboronic acid (4441-56-9) + camptothecin (7689-03-4,91926-09-9) → (S)-11-cyclohexyl-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano-[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione (78287-30-6)

Guidance literature:

With tris(2,2'-bipyridyl)ruthenium dichloride; 1-acetoxy-1,2-benziodoxol-3-one; at 30 ℃; for 5h; Inert atmosphere; Irradiation;

DOI:10.1039/c6sc02653b

Reference yield: 49.0%

camptothecin (7689-03-4,91926-09-9) + cyclohexanecarbaldehyde (2043-61-0) → (S)-11-cyclohexyl-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano-[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione (78287-30-6)

Guidance literature:

With sulfuric acid; water; dihydrogen peroxide; acetic acid; at 0 - 5 ℃; for 3h;

DOI:10.1016/j.bmcl.2009.06.010

Reference yield: 48.0%

camptothecin (7689-03-4,91926-09-9) + 1,3-dioxoisoindolin-2-yl cyclohexanecarboxylate (126812-30-4) → (S)-11-cyclohexyl-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano-[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione (78287-30-6)

Guidance literature:

With potassium indole-N-carbodithioate; trifluorormethanesulfonic acid; In dimethyl sulfoxide; at 40 ℃; for 24h; Inert atmosphere; Irradiation;

DOI:10.1021/jacs.1c05607

upstream raw materials:

camptothecin

cyclohexylmethyl alcohol

cyclohexanecarbaldehyde

cyclohexanone