126812-30-4Relevant articles and documents
Visible-light-induced regioselective alkylation of coumarins via decarboxylative coupling with N-hydroxyphthalimide esters
Jin, Can,Yan, Zhiyang,Sun, Bin,Yang, Jin
, p. 2064 - 2068 (2019)
An efficient photocatalytic decarboxylative 3-position alkylation of coumarins by using alkyl N-hydroxyphthalimide esters as alkylation reagents has been developed. A variety of NHP esters derived from aliphatic carboxylic acids (primary, secondary, and tertiary) has been proved to be tolerated for this decarboxylation process, affording a broad scope of 3-alkylated coumarin derivatives in moderate to excellent yields. This protocol was highlighted by its mild conditions, readily available starting materials, operational simplicity, and wide functional group tolerance.
Visible Light-Induced Regioselective Decarboxylative Alkylation of the C(sp2)?H Bonds of Non-Aromatic Heterocycles
Liu, Lixin,Pan, Neng,Sheng, Wei,Su, Lebin,Liu, Long,Dong, Jianyu,Zhou, Yongbo,Yin, Shuang-Feng
, p. 4126 - 4132 (2019)
With sunlight or blue LEDs irradiation, regioselective decarboxylative alkylation of various non-aromatic heterocycles has been realized via C(sp3)-centered radical C(sp2)?C(sp3) bond formation under oxidant-free condition
Catalyst-free Decarboxylation and Decarboxylative Giese Additions of Alkyl Carboxylates through Photoactivation of Electron Donor-Acceptor Complex
Zheng, Chao,Wang, Guang-Zu,Shang, Rui
, p. 4500 - 4505 (2019)
We report herein a catalyst-free method to perform decarboxylative conjugated addition and hydrodecarboxylation of aliphatic N-(acyloxy)phthalimides (redox active esters, RAEs) through photoactivation of electron-donor-acceptor (EDA) complex with Hantzsch ester (HE) in N,N-dimethylacetamide (DMA) solution. The reactions present a green method to decarboxylatively construct carbon-carbon bond and to perform hydrodecarboxylation with broad substrate scope and functional group tolerance under mild blue light irradiation condition without recourse of popularly used photoredox catalysts. (Figure presented.).
Electroreductive Cross-Coupling of Trifluoromethyl Alkenes and Redox Active Esters for the Synthesis of Gem-Difluoroalkenes
Claraz, Aurélie,Allain, Clémence,Masson, Géraldine
supporting information, (2021/11/17)
An electroreductive access to gem-difluoroalkenes has been developed through the decarboxylative/defluorinative coupling of N-hydroxyphtalimides esters and α-trifluoromethyl alkenes. The electrolysis is performed under very simple reaction conditions in a
Substrate for synthesizing beta-Se amino acid as well as preparation method and application of substrate
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Paragraph 0070-0077, (2021/08/14)
The invention discloses a substrate for synthesizing beta-Se amino acid as well as a preparation method and application of the substrate, and the beta-Se amino acid is almost seldom synthesized by a method except selenocysteine at present. A substrate (namely a formula (I)) for synthesizing beta-Se amino acid is autonomously designed, and different beta-Se amino acids can be obtained only by changing a free radical precursor generated by photoreaction by using a general intermediate (namely the formula (I)) which is newly designed in the invention, so that divergent synthesis of the beta-Se amino acids is realized. According to the method for synthesizing the beta-Se amino acid, synthesis can be simply and efficiently achieved, good functional group compatibility can be achieved, the yield is generally high, and the application range of natural chemical connection is further expanded.
