N-(3-{3-[2-(3-chloro-phenylamino)-pyrimidin-4-yl]-pyridin-2-ylamino}-propyl)-acetamide

Base Information

Chemical Name:N-(3-{3-[2-(3-chloro-phenylamino)-pyrimidin-4-yl]-pyridin-2-ylamino}-propyl)-acetamide
CAS No.:1035944-09-2
Molecular Formula:C₂₀H₂₁ClN₆O
Molecular Weight:396.879
Hs Code.:

Synonyms:N-(3-{3-[2-(3-chloro-phenylamino)-pyrimidin-4-yl]-pyridin-2-ylamino}-propyl)-acetamide

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Chemical Property of N-(3-{3-[2-(3-chloro-phenylamino)-pyrimidin-4-yl]-pyridin-2-ylamino}-propyl)-acetamide

Chemical Property:

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Technology Process of N-(3-{3-[2-(3-chloro-phenylamino)-pyrimidin-4-yl]-pyridin-2-ylamino}-propyl)-acetamide

There total 4 articles about N-(3-{3-[2-(3-chloro-phenylamino)-pyrimidin-4-yl]-pyridin-2-ylamino}-propyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1035943-89-5
N-{3-[2-(3-chloro-phenylamino)-pyrimidin-4-yl]-pyridin-2-yl}-propane-1,3-diamine

: 108-24-7
acetic anhydride

: 1035944-09-2
N-(3-{3-[2-(3-chloro-phenylamino)-pyrimidin-4-yl]-pyridin-2-ylamino}-propyl)-acetamide

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 0.333333h;

Reference yield:

: 381248-04-0
(2-chloropyridin-3-yl)boronic acid

: 1035944-09-2
N-(3-{3-[2-(3-chloro-phenylamino)-pyrimidin-4-yl]-pyridin-2-ylamino}-propyl)-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 14 h / 95 °C

2: toluene-4-sulfonic acid / 1,4-dioxane / 1.5 h / 110 °C / Sealed tube

3: 0.5 h / 110 °C / Sealed tube

4: tetrahydrofuran / 0.33 h / 20 °C

With sodium carbonate; toluene-4-sulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 870221-39-9
2-chloro-4-(2-chloro-pyridin-3-yl)-pyrimidine

: 1035944-09-2
N-(3-{3-[2-(3-chloro-phenylamino)-pyrimidin-4-yl]-pyridin-2-ylamino}-propyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / 1,4-dioxane / 1.5 h / 110 °C / Sealed tube

2: 0.5 h / 110 °C / Sealed tube

3: tetrahydrofuran / 0.33 h / 20 °C

With toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane;