5-(3-chloropropyl)-1-<(4-cyanophenyl)methyl>-1H-imidazole hydrochloride

Base Information

• Chemical Name: 5-(3-chloropropyl)-1-<(4-cyanophenyl)methyl>-1H-imidazole hydrochloride
• CAS No.: 102676-90-4
• Molecular Formula: C₁₄H₁₄ClN₃*ClH
• Molecular Weight: 296.199
• Mol file: 102676-90-4.mol

Synonyms:5-(3-chloropropyl)-1-<(4-cyanophenyl)methyl>-1H-imidazole hydrochloride

Chemical Property of 5-(3-chloropropyl)-1-<(4-cyanophenyl)methyl>-1H-imidazole hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(3-chloropropyl)-1-<(4-cyanophenyl)methyl>-1H-imidazole hydrochloride

There total 3 articles about 5-(3-chloropropyl)-1-<(4-cyanophenyl)methyl>-1H-imidazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-<(4-cyanophenyl)methyl>-1H-imidazole-5-propanol (102676-29-9) → 5-(3-chloropropyl)-1-<(4-cyanophenyl)methyl>-1H-imidazole hydrochloride (102676-90-4)

Guidance literature:

With thionyl chloride; In dichloromethane; for 1.5h; Heating;

DOI:10.1021/jm00106a038

Reference yield:

4-(3-hydroxypropyl)-1H-imidazole (49549-75-9) → 5-(3-chloropropyl)-1-<(4-cyanophenyl)methyl>-1H-imidazole hydrochloride (102676-90-4)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / acetonitrile / 21 h / Heating

2: Et₃N / acetonitrile / 1 h

4: 94 percent / SOCl₂ / CH₂Cl₂ / 1.5 h / Heating

With thionyl chloride; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1021/jm00106a038

Reference yield:

N,N-dimethyl-4-[3-[(trimethylsilyl)oxy]propyl]-1H-imidazole-1-carboxamide (102676-27-7) → 5-(3-chloropropyl)-1-<(4-cyanophenyl)methyl>-1H-imidazole hydrochloride (102676-90-4)

Guidance literature:

Multi-step reaction with 2 steps

2: 94 percent / SOCl₂ / CH₂Cl₂ / 1.5 h / Heating

With thionyl chloride; In dichloromethane;

DOI:10.1021/jm00106a038

upstream raw materials:

1-<(4-cyanophenyl)methyl>-1H-imidazole-5-propanol

4-(3-hydroxypropyl)-1H-imidazole

N,N-dimethyl-4-[3-[(trimethylsilyl)oxy]propyl]-1H-imidazole-1-carboxamide