3-(1H-Imidazol-4-yl)-1-propanol

Base Information

• Chemical Name: 3-(1H-Imidazol-4-yl)-1-propanol
• CAS No.: 49549-75-9
• Molecular Formula: C6H10 N2 O
• Molecular Weight: 126.16
• Mol file: 49549-75-9.mol

Synonyms:1H-Imidazole-4-propanol(9CI); 3-(1H-Imidazol-4-yl)-1-propanol; 4-(3-Hydroxypropyl)imidazole;Imidazole-4-propanol

Chemical Property of 3-(1H-Imidazol-4-yl)-1-propanol

Chemical Property:

• Boiling Point: 371.1±17.0 °C(Predicted)
• PKA: 14.54±0.10(Predicted)
• PSA: 48.91000
• Density: 1.170±0.06 g/cm3(Predicted)
• LogP: 0.33460

Purity/Quality:

97% ^*data from raw suppliers

3-(1H-Imidazol-5-yl)propan-1-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(1H-Imidazol-4-yl)-1-propanol

There total 12 articles about 3-(1H-Imidazol-4-yl)-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

urocanic acid (104-98-3) → 4-(3-hydroxypropyl)-1H-imidazole (49549-75-9)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1016/j.bmcl.2005.12.074

Reference yield: 86.6%

methyl 3-(4-imidazolyl)propionate (31434-93-2) → 4-(3-hydroxypropyl)-1H-imidazole (49549-75-9)

Guidance literature:

methyl 3-(4-imidazolyl)propionate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 50 ℃; for 5h;

With potassium hydroxide; water; In tetrahydrofuran; for 0.5h; Heating / reflux;

Reference yield: 86.6%

aqueous potassium hydroxide + methyl 3-(4-imidazolyl)propionate (31434-93-2) → 4-(3-hydroxypropyl)-1H-imidazole (49549-75-9)

Guidance literature:

upstream raw materials:

ethyl 3-(imidazol-4'-yl)-propanoate

3-bromo-2-methoxy-tetrahydropyran

formamide

urocanic acid

Downstream raw materials:

3-(1-trityl-1H-imidazol-4-yl)propan-1-ol

1-<(4-cyanophenyl)methyl>-1H-imidazole-5-propanol

5-(3-chloropropyl)-1-<(4-cyanophenyl)methyl>-1H-imidazole hydrochloride

1-triphenylmethyl-4-[3-(4-fluorophenoxy)propyl]-1H-imidazole