[2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]acetic acid hydrazide

Base Information

• Chemical Name: [2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]acetic acid hydrazide
• CAS No.: 885500-91-4
• Molecular Formula: C₁₇H₁₆N₄O₃
• Molecular Weight: 324.339

Synonyms:[2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]acetic acid hydrazide

Chemical Property of [2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]acetic acid hydrazide

Chemical Property:

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Technology Process of [2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]acetic acid hydrazide

There total 2 articles about [2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]acetic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethyl [2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]-acetate (885500-90-3) → [2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]acetic acid hydrazide (885500-91-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 5h; Heating;

DOI:10.1002/jhet.5570430235

Reference yield:

1,2-dihydro-3-(4-methoxyphenyl)-1,8-naphthyridin-2(1H)-one (477849-11-9) → [2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]acetic acid hydrazide (885500-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / K₂CO₃ / dimethylformamide / 0.07 h / microwave irradiation

2: 93 percent / hydrazine hydrate / ethanol / 5 h / Heating

With potassium carbonate; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570430235

Reference yield: 98.0%

[2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]acetic acid hydrazide (885500-91-4) + 4-methyl-benzaldehyde (104-87-0) → [3-(4-methoxy-phenyl)-2-oxo-2H-[1,8]naphthyridin-1-yl]-acetic acid (4-methyl-benzylidene)-hydrazide (885500-93-6)

Guidance literature:

With N,N-dimethyl-formamide; for 0.0166667h; microwave irradiation;

DOI:10.1002/jhet.5570430235

upstream raw materials:

ethyl [2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]-acetate

1,2-dihydro-3-(4-methoxyphenyl)-1,8-naphthyridin-2(1H)-one

Downstream raw materials:

[3-(4-methoxy-phenyl)-2-oxo-2H-[1,8]naphthyridin-1-yl]-acetic acid (4-methyl-benzylidene)-hydrazide

[3-(4-Methoxy-phenyl)-2-oxo-2H-[1,8]naphthyridin-1-yl]-acetic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide

[3-(4-Methoxy-phenyl)-2-oxo-2H-[1,8]naphthyridin-1-yl]-acetic acid [1-(2-chloro-phenyl)-meth-(E)-ylidene]-hydrazide

[3-(4-Methoxy-phenyl)-2-oxo-2H-[1,8]naphthyridin-1-yl]-acetic acid [1-(3-nitro-phenyl)-meth-(E)-ylidene]-hydrazide

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