ethyl [2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]-acetate

Base Information

• Chemical Name: ethyl [2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]-acetate
• CAS No.: 885500-90-3
• Molecular Formula: C₁₉H₁₈N₂O₄
• Molecular Weight: 338.363
• Mol file: 885500-90-3.mol

Synonyms:ethyl [2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]-acetate

Chemical Property of ethyl [2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]-acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl [2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]-acetate

There total 1 articles about ethyl [2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

chloroacetic acid ethyl ester (105-39-5) + 1,2-dihydro-3-(4-methoxyphenyl)-1,8-naphthyridin-2(1H)-one (477849-11-9) → ethyl [2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]-acetate (885500-90-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 0.0666667h; microwave irradiation;

DOI:10.1002/jhet.5570430235

Reference yield: 93.0%

ethyl [2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]-acetate (885500-90-3) → [2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]acetic acid hydrazide (885500-91-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 5h; Heating;

DOI:10.1002/jhet.5570430235

Reference yield:

ethyl [2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]-acetate (885500-90-3) → [3-(4-methoxy-phenyl)-2-oxo-2H-[1,8]naphthyridin-1-yl]-acetic acid (4-methyl-benzylidene)-hydrazide (885500-93-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / hydrazine hydrate / ethanol / 5 h / Heating

2: 98 percent / DMF / 0.02 h / microwave irradiation

With hydrazine hydrate; N,N-dimethyl-formamide; In ethanol;

DOI:10.1002/jhet.5570430235

upstream raw materials:

chloroacetic acid ethyl ester

1,2-dihydro-3-(4-methoxyphenyl)-1,8-naphthyridin-2(1H)-one

Downstream raw materials:

[2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]acetic acid hydrazide

[2-oxo-3-(p-methoxyphenyl)-2H-[1,8]naphthyridin-1-yl]acetic acid benzylidenehydrazide

[3-(4-Methoxy-phenyl)-2-oxo-2H-[1,8]naphthyridin-1-yl]-acetic acid [1-(2-bromo-phenyl)-meth-(E)-ylidene]-hydrazide

[3-(4-methoxy-phenyl)-2-oxo-2H-[1,8]naphthyridin-1-yl]-acetic acid (4-methyl-benzylidene)-hydrazide