(1R,2R,4R)-5-(tert-butyldiphenylsilanyloxy)-2-(hex-5-enyl-methylcarbamoyl)cyclohexanecarboxylic acid tert-butyl ester

Base Information

Chemical Name:(1R,2R,4R)-5-(tert-butyldiphenylsilanyloxy)-2-(hex-5-enyl-methylcarbamoyl)cyclohexanecarboxylic acid tert-butyl ester
CAS No.:1265883-89-3
Molecular Formula:C₃₅H₅₁NO₄Si
Molecular Weight:577.88
Hs Code.:

Synonyms:(1R,2R,4R)-5-(tert-butyldiphenylsilanyloxy)-2-(hex-5-enyl-methylcarbamoyl)cyclohexanecarboxylic acid tert-butyl ester

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Chemical Property of (1R,2R,4R)-5-(tert-butyldiphenylsilanyloxy)-2-(hex-5-enyl-methylcarbamoyl)cyclohexanecarboxylic acid tert-butyl ester

Chemical Property:

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Technology Process of (1R,2R,4R)-5-(tert-butyldiphenylsilanyloxy)-2-(hex-5-enyl-methylcarbamoyl)cyclohexanecarboxylic acid tert-butyl ester

There total 11 articles about (1R,2R,4R)-5-(tert-butyldiphenylsilanyloxy)-2-(hex-5-enyl-methylcarbamoyl)cyclohexanecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1108656-90-1
N-methylhex-5-en-1-amine tosylate salt

: 1265883-88-2
(1R,2R,4R)-4-(tert-butyldiphenylsilanyloxy)cyclohexane-1,2-dicarboxylic acid 2-tert-butyl ester

: 1265883-89-3
(1R,2R,4R)-5-(tert-butyldiphenylsilanyloxy)-2-(hex-5-enyl-methylcarbamoyl)cyclohexanecarboxylic acid tert-butyl ester

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 323196-38-9
(1R,2R)-cyclohex-4-ene 1,2-dicarboxylic acid monomethyl ester

: 1265883-89-3
(1R,2R,4R)-5-(tert-butyldiphenylsilanyloxy)-2-(hex-5-enyl-methylcarbamoyl)cyclohexanecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium iodide; sodium hydrogencarbonate; iodine / dichloromethane; water / 48 h

2.1: tris-(trimethylsilyl)silane / 2,2'-azobis(isobutyronitrile) / toluene / 1.5 h / 90 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / Inert atmosphere

4.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: hydrogen / palladium on carbon / ethanol / 16 h / Inert atmosphere

6.1: toluene / 1.5 h / 110 °C / Reflux

7.1: lithium hydroxide / water; tetrahydrofuran / 16 h / 20 °C

7.2: pH 2

8.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; tris-(trimethylsilyl)silane; O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate; hydrogen; iodine; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; lithium hydroxide; 2,2'-azobis(isobutyronitrile); palladium on carbon; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1265882-89-0,188796-05-6
(1R,2R,5R)-7-oxo-6-oxabicyclo[3,2,1]octane-2-carboxylic acid methyl ester

: 1265883-89-3
(1R,2R,4R)-5-(tert-butyldiphenylsilanyloxy)-2-(hex-5-enyl-methylcarbamoyl)cyclohexanecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: hydrogen / palladium on carbon / ethanol / 16 h / Inert atmosphere

4.1: toluene / 1.5 h / 110 °C / Reflux

5.1: lithium hydroxide / water; tetrahydrofuran / 16 h / 20 °C

5.2: pH 2

6.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; palladium on carbon; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene;