323196-38-9

Upstream product

• 31139-02-3 (1R,6S)-6-methoxycarbonyl-3-cyclohexene-1-carboxylic acid 
• 116733-43-8 (1R,6R)-6-(2-oxo-oxazolidine-3-carbonyl)-cyclohex-3-ene carboxylic acid methyl ester 
• 116733-42-7 3-[(E)-3-(methoxycarbonyl)-propenoyl]-oxazolidin-2-one 

Downstream Products

• 323196-39-0 (1R,6R)-6-tert-butoxycarbonylamino-cyclohex-3-ene carboxylic acid methyl ester 
• 323196-40-3 (1R,6R)-6-tert-butoxycarbonylamino-cyclohex-3-ene carboxylic acid 
• 1265883-91-7 (1R,2S)-methyl 1-((1R,2R,5R)-5-(tert-butyldiphenylsilyloxy)-2-(hex-5-enyl(methyl)carbamoyl)cyclohexanecarboxamido)-2-vinylcyclopropanecarboxylate 
• 1265882-93-6 (1R,2R,4R)-2-(hex-5-enylmethylcarbamoyl)-5-[7-methoxy-8-methyl-2-(4-trifluoromethylthiazol-2-yl)quinolin-4-yloxy]cyclohexane carboxylic acid benzyl ester 
• 1265882-92-5 (1R,2R,4R)-4-[7-methoxy-8-methyl-2-(4-trifluoromethylthiazol-2-yl)quinolin-4-yloxy]cyclohexane-1,2-dicarboxylic acid 2-benzyl ester 
• 1265882-91-4 (1R,2R,4R)-4-[7-methoxy-8-methyl-2-(4-trifluoromethylthiazol-2-yl)-quinolin-4-yloxy]cyclohexane-1,2-dicarboxylic acid 2-benzyl ester 1-methyl ester 
• 1265882-90-3 (1R,2R,4R)-4-hydroxy-cyclohexane-1,2-dicarboxylic acid 2-benzyl ester 1-methyl ester 
• 1265882-89-0 (1R,2R,5R)-7-oxo-6-oxabicyclo[3,2,1]octane-2-carboxylic acid methyl ester 
• 1265883-90-6 (1R,2R,4R)-5-(tert-butyldiphenylsilanyloxy)-2-(hex-5-enyl-methylcarbamoyl)cyclohexanecarboxylic acid 
• 1265883-89-3 (1R,2R,4R)-5-(tert-butyldiphenylsilanyloxy)-2-(hex-5-enyl-methylcarbamoyl)cyclohexanecarboxylic acid tert-butyl ester 
• 1265883-88-2 (1R,2R,4R)-4-(tert-butyldiphenylsilanyloxy)cyclohexane-1,2-dicarboxylic acid 2-tert-butyl ester 
• 1265883-87-1 (1R,2R,4R)-4-(tert-butyldiphenylsilanyloxy)cyclohexane-1,2-dicarboxylic acid 2-tert-butyl ester 1-methyl ester 
• 1265883-86-0 (1R,2R,4R)-4-(tert-butyldiphenylsilanyloxy)cyclohexane-1,2-dicarboxylic acid 1-methyl ester 
• 1265883-85-9 (1R,2R,4R)-4-(tert-butyldiphenylsilanyloxy)cyclohexane-1,2-dicarboxylic acid 2-benzyl ester 1-methyl ester 

Relevant academic research and scientific papers

Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections

Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula I, and pharmaceutical compositions and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.

MACROCYCLIC SERINE PROTEASE INHIBITORS USEFUL AGAINST VIRAL INFECTIONS, PARTICULARLY HCV

Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula (Ia) or (Ib), pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.

2-Azidoethoxy derivatives of 2-aminocyclohexanecarboxylic acids (ACHC): Interesting building blocks for the synthesis of cyclic β-peptide conjugates

Oligomers of cyclic-β-aminoacids possess a high resistance to peptidase-catalyzed hydrolysis and display a high intrinsic tendency to adopt regular secondary structures. These characteristics are attractive to develop new biologically active substances. H

Diels-Alder approaches to ring-functionalized cyclic β-amino acids

Catalytic asymmetric Diels-Alder reactions with aminodiene 1 and desymmetrized fumarate 8 were used for efficient access to dihydroxylated cis- and trans-aminocyclohexane β-amino acids. (C) 2000 Elsevier Science Ltd.