N-tert-butoxycarbonyl-L-phenylalanyl-L-proline 9-fluorenylmethyl thioester

Base Information

• Chemical Name: N-tert-butoxycarbonyl-L-phenylalanyl-L-proline 9-fluorenylmethyl thioester
• CAS No.: 1330059-31-8
• Molecular Formula: C₃₃H₃₆N₂O₄S
• Molecular Weight: 556.726

Synonyms:N-tert-butoxycarbonyl-L-phenylalanyl-L-proline 9-fluorenylmethyl thioester

Chemical Property of N-tert-butoxycarbonyl-L-phenylalanyl-L-proline 9-fluorenylmethyl thioester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N-tert-butoxycarbonyl-L-phenylalanyl-L-proline 9-fluorenylmethyl thioester

There total 4 articles about N-tert-butoxycarbonyl-L-phenylalanyl-L-proline 9-fluorenylmethyl thioester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

NH-L-proline 9-fluorenylmethyl thioester (1279109-29-3) + N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → N-tert-butoxycarbonyl-L-phenylalanyl-L-proline 9-fluorenylmethyl thioester (1330059-31-8)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1021/ja2065158

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) → N-tert-butoxycarbonyl-L-phenylalanyl-L-proline 9-fluorenylmethyl thioester (1330059-31-8)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

With dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja2065158

Reference yield:

(9H-fluoren-9-yl)methanethiol (957753-00-3) → N-tert-butoxycarbonyl-L-phenylalanyl-L-proline 9-fluorenylmethyl thioester (1330059-31-8)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

With dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja2065158

upstream raw materials:

(9H-fluoren-9-yl)methanethiol

NH-L-proline 9-fluorenylmethyl thioester

N-tert-butoxycarbonyl-L-phenylalanine

1-(tert-butoxycarbonyl)-L-proline

Downstream raw materials:

Boc-L-Phe-L-Pro-SH

N-tert-butoxycarbonyl-L-phenylalanyl-L-prolyl-L-alanine ethyl ester

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