5-[(R)-2-{[2-(3-aminophenyl)ethyl]benzylamino}-1-(teRt-butyl-dimethylsilanyloxy)ethyl]-8-benzyloxy-1H-quinolin-2-one

Base Information

Chemical Name:5-[(R)-2-{[2-(3-aminophenyl)ethyl]benzylamino}-1-(teRt-butyl-dimethylsilanyloxy)ethyl]-8-benzyloxy-1H-quinolin-2-one
CAS No.:1253582-07-8
Molecular Formula:C₃₉H₄₇N₃O₃Si
Molecular Weight:633.906
Hs Code.:

Synonyms:5-[(R)-2-{[2-(3-aminophenyl)ethyl]benzylamino}-1-(teRt-butyl-dimethylsilanyloxy)ethyl]-8-benzyloxy-1H-quinolin-2-one

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Chemical Property of 5-[(R)-2-{[2-(3-aminophenyl)ethyl]benzylamino}-1-(teRt-butyl-dimethylsilanyloxy)ethyl]-8-benzyloxy-1H-quinolin-2-one

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Technology Process of 5-[(R)-2-{[2-(3-aminophenyl)ethyl]benzylamino}-1-(teRt-butyl-dimethylsilanyloxy)ethyl]-8-benzyloxy-1H-quinolin-2-one

There total 5 articles about 5-[(R)-2-{[2-(3-aminophenyl)ethyl]benzylamino}-1-(teRt-butyl-dimethylsilanyloxy)ethyl]-8-benzyloxy-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₈H₆₁N₃O₃Si

: 1253582-07-8
5-[(R)-2-{[2-(3-aminophenyl)ethyl]benzylamino}-1-(teRt-butyl-dimethylsilanyloxy)ethyl]-8-benzyloxy-1H-quinolin-2-one

Guidance literature:: C₅₈H₆₁N₃O₃Si; With hydrogenchloride; water; In acetonitrile; at 20 ℃; for 1h; pH=< 2; Inert atmosphere;

With sodium hydrogencarbonate; In water; acetonitrile; pH=7 - 8;

Reference yield:

: 1253582-04-5
[3-(tritylamino)phenyl]acetic acid

: 1253582-07-8
5-[(R)-2-{[2-(3-aminophenyl)ethyl]benzylamino}-1-(teRt-butyl-dimethylsilanyloxy)ethyl]-8-benzyloxy-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 18.75 h / 1.8 - 20 °C / Inert atmosphere

1.2: 20 °C

2.1: 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane / 0.75 h / 0 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / acetonitrile / 18 h / 75 °C / Inert atmosphere

4.1: hydrogenchloride; water / acetonitrile / 1 h / 20 °C / pH < 2 / Inert atmosphere

4.2: pH 7 - 8

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; dimethylsulfide borane complex; water; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 1253582-06-7
4-nitrobenzenesulfonic acid 2-[3-(tritylamino)phenyl]ethyl ester

: 1253582-07-8
5-[(R)-2-{[2-(3-aminophenyl)ethyl]benzylamino}-1-(teRt-butyl-dimethylsilanyloxy)ethyl]-8-benzyloxy-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / acetonitrile / 18 h / 75 °C / Inert atmosphere

2.1: hydrogenchloride; water / acetonitrile / 1 h / 20 °C / pH < 2 / Inert atmosphere

2.2: pH 7 - 8

With hydrogenchloride; water; sodium hydrogencarbonate; In acetonitrile;