dicyclopropyl{5-[3-(morpholin-4-yl)-5-nitrophenyl]-1,3-thiazol-2-yl}methanol

Base Information

Chemical Name:dicyclopropyl{5-[3-(morpholin-4-yl)-5-nitrophenyl]-1,3-thiazol-2-yl}methanol
CAS No.:1312537-00-0
Molecular Formula:C₂₀H₂₃N₃O₄S
Molecular Weight:401.486
Hs Code.:

Synonyms:dicyclopropyl{5-[3-(morpholin-4-yl)-5-nitrophenyl]-1,3-thiazol-2-yl}methanol

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Chemical Property of dicyclopropyl{5-[3-(morpholin-4-yl)-5-nitrophenyl]-1,3-thiazol-2-yl}methanol

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Technology Process of dicyclopropyl{5-[3-(morpholin-4-yl)-5-nitrophenyl]-1,3-thiazol-2-yl}methanol

There total 3 articles about dicyclopropyl{5-[3-(morpholin-4-yl)-5-nitrophenyl]-1,3-thiazol-2-yl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1121-37-5
dicyclopropyl ketone

: 1312537-00-0
dicyclopropyl{5-[3-(morpholin-4-yl)-5-nitrophenyl]-1,3-thiazol-2-yl}methanol

Guidance literature:: Multi-step reaction with 3 steps

1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

2: bromine; sodium acetate / acetic acid / 4 h / 20 °C

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 0.58 h / 130 °C / Microwave irradiation

With n-butyllithium; bromine; sodium acetate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,2-dimethoxyethane; acetic acid;

Reference yield:

: 1051899-19-4
4-(3-iodo-5-nitrophenyl)-morpholine

: 1312537-00-0
dicyclopropyl{5-[3-(morpholin-4-yl)-5-nitrophenyl]-1,3-thiazol-2-yl}methanol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 0.5 h / 125 °C / Inert atmosphere; Microwave irradiation

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 0.58 h / 130 °C / Microwave irradiation

With potassium acetate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; dimethyl sulfoxide;

Reference yield:

: 356556-42-8
dicyclopropyl(1,3-thiazole-2-yl)methanol

: 1312537-00-0
dicyclopropyl{5-[3-(morpholin-4-yl)-5-nitrophenyl]-1,3-thiazol-2-yl}methanol

Guidance literature:: Multi-step reaction with 2 steps

1: bromine; sodium acetate / acetic acid / 4 h / 20 °C

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 0.58 h / 130 °C / Microwave irradiation

With bromine; sodium acetate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; acetic acid;