{5-[3-amino-5-(morpholin-4-yl)phenyl]-1,3-thiazol-2-yl}(dicyclopropyl)methanol

Base Information

Chemical Name:{5-[3-amino-5-(morpholin-4-yl)phenyl]-1,3-thiazol-2-yl}(dicyclopropyl)methanol
CAS No.:1312537-01-1
Molecular Formula:C₂₀H₂₅N₃O₂S
Molecular Weight:371.503
Hs Code.:

Synonyms:{5-[3-amino-5-(morpholin-4-yl)phenyl]-1,3-thiazol-2-yl}(dicyclopropyl)methanol

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Chemical Property of {5-[3-amino-5-(morpholin-4-yl)phenyl]-1,3-thiazol-2-yl}(dicyclopropyl)methanol

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Technology Process of {5-[3-amino-5-(morpholin-4-yl)phenyl]-1,3-thiazol-2-yl}(dicyclopropyl)methanol

There total 6 articles about {5-[3-amino-5-(morpholin-4-yl)phenyl]-1,3-thiazol-2-yl}(dicyclopropyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1312537-00-0
dicyclopropyl{5-[3-(morpholin-4-yl)-5-nitrophenyl]-1,3-thiazol-2-yl}methanol

: 1312537-01-1
{5-[3-amino-5-(morpholin-4-yl)phenyl]-1,3-thiazol-2-yl}(dicyclopropyl)methanol

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1121-37-5
dicyclopropyl ketone

: 1312537-01-1
{5-[3-amino-5-(morpholin-4-yl)phenyl]-1,3-thiazol-2-yl}(dicyclopropyl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

2: bromine; sodium acetate / acetic acid / 4 h / 20 °C

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 0.58 h / 130 °C / Microwave irradiation

4: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h / 20 °C / Inert atmosphere

With n-butyllithium; hydrogen; bromine; sodium acetate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,2-dimethoxyethane; acetic acid; ethyl acetate;

Reference yield:

: 1129540-90-4
4-[3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine

: 1312537-01-1
{5-[3-amino-5-(morpholin-4-yl)phenyl]-1,3-thiazol-2-yl}(dicyclopropyl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 0.58 h / 130 °C / Microwave irradiation

2: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h / 20 °C / Inert atmosphere

With hydrogen; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In 1,2-dimethoxyethane; ethyl acetate;