4-methyl-N-prop-1-ynyl-N-(2-trimethylsilanylethynyl-phenyl)-benzenesulfonamide

Base Information

Chemical Name:4-methyl-N-prop-1-ynyl-N-(2-trimethylsilanylethynyl-phenyl)-benzenesulfonamide
CAS No.:1313483-52-1
Molecular Formula:C₂₁H₂₃NO₂SSi
Molecular Weight:381.571
Hs Code.:

Synonyms:4-methyl-N-prop-1-ynyl-N-(2-trimethylsilanylethynyl-phenyl)-benzenesulfonamide

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Chemical Property of 4-methyl-N-prop-1-ynyl-N-(2-trimethylsilanylethynyl-phenyl)-benzenesulfonamide

Chemical Property:

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Technology Process of 4-methyl-N-prop-1-ynyl-N-(2-trimethylsilanylethynyl-phenyl)-benzenesulfonamide

There total 5 articles about 4-methyl-N-prop-1-ynyl-N-(2-trimethylsilanylethynyl-phenyl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1148038-46-3
N-ethynyl-4-methyl-N-(2-((trimethylsilyl)ethynyl)phenyl)benzenesulfonamide

: 74-88-4
methyl iodide

: 1313483-52-1
4-methyl-N-prop-1-ynyl-N-(2-trimethylsilanylethynyl-phenyl)-benzenesulfonamide

Guidance literature:: N-ethynyl-4-methyl-N-(2-((trimethylsilyl)ethynyl)phenyl)benzenesulfonamide; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - -40 ℃; for 1h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at -40 - 20 ℃; Inert atmosphere;
DOI:10.1039/c1cc11298h

Reference yield:

: 615-43-0
2-iodophenylamine

: 1313483-52-1
4-methyl-N-prop-1-ynyl-N-(2-trimethylsilanylethynyl-phenyl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2.1: pyridine / tetrahydrofuran / 20 °C / Inert atmosphere

3.1: potassium hexamethylsilazane / toluene / 0.5 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - -40 °C / Inert atmosphere

4.2: -40 - 20 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium hexamethylsilazane; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 1.1: Sonogashira coupling;
DOI:10.1039/c1cc11298h

Reference yield:

: 103529-16-4
2-[(trimethylsilyl)ethynyl]aniline

: 1313483-52-1
4-methyl-N-prop-1-ynyl-N-(2-trimethylsilanylethynyl-phenyl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: potassium hexamethylsilazane / toluene / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - -40 °C / Inert atmosphere

3.2: -40 - 20 °C / Inert atmosphere

With pyridine; potassium hexamethylsilazane; lithium hexamethyldisilazane; In tetrahydrofuran; toluene;
DOI:10.1039/c1cc11298h