acetic acid 1-(2-(3,3-dimethyl-but-1-ynyl)-phenyl)-3-trimethylsilanyl-buta-1,2-dienyl ester

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Chemical Name:acetic acid 1-(2-(3,3-dimethyl-but-1-ynyl)-phenyl)-3-trimethylsilanyl-buta-1,2-dienyl ester
CAS No.:294190-56-0
Molecular Formula:C₂₁H₂₈O₂Si
Molecular Weight:340.538
Hs Code.:

Synonyms:acetic acid 1-(2-(3,3-dimethyl-but-1-ynyl)-phenyl)-3-trimethylsilanyl-buta-1,2-dienyl ester

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Chemical Property of acetic acid 1-(2-(3,3-dimethyl-but-1-ynyl)-phenyl)-3-trimethylsilanyl-buta-1,2-dienyl ester

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Technology Process of acetic acid 1-(2-(3,3-dimethyl-but-1-ynyl)-phenyl)-3-trimethylsilanyl-buta-1,2-dienyl ester

There total 5 articles about acetic acid 1-(2-(3,3-dimethyl-but-1-ynyl)-phenyl)-3-trimethylsilanyl-buta-1,2-dienyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 917-54-4
methyllithium

: 108-24-7
acetic anhydride

: 294190-50-4
1-(2-(3,3-dimethyl-but-1-ynyl)-phenyl)-3-trimethylsilanyl-propynone

: 294190-56-0
acetic acid 1-(2-(3,3-dimethyl-but-1-ynyl)-phenyl)-3-trimethylsilanyl-buta-1,2-dienyl ester

Guidance literature:: methyllithium; 1-(2-(3,3-dimethyl-but-1-ynyl)-phenyl)-3-trimethylsilanyl-propynone; With copper(l) iodide; In diethyl ether;

acetic anhydride; In diethyl ether; at -78 - 25 ℃; for 2h; Further stages.;
DOI:10.1021/jo991876v

Reference yield:

: 88-67-5
2-Iodobenzoic acid

: 294190-56-0
acetic acid 1-(2-(3,3-dimethyl-but-1-ynyl)-phenyl)-3-trimethylsilanyl-buta-1,2-dienyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl chloride; DMF / CH₂Cl₂ / 2 h / 25 °C

2.1: 5.64 g / pyridine / CH₂Cl₂ / 12 h / 25 °C

3.1: 66 percent / Pd(PPh₃)4; CuI; n-BuNH₂ / tetrahydrofuran / 2 h / 25 °C

4.1: 83 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / 0 - 25 °C

5.1: CuI / diethyl ether

5.2: 71 percent / diethyl ether / 2 h / -78 - 25 °C

With pyridine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; oxalyl dichloride; N-butylamine; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; 1.1: Substitution / 2.1: Substitution / 3.1: Substitution / 4.1: Addition / 5.1: Addition / 5.2: Acetylation;
DOI:10.1021/jo991876v

Reference yield:

: 609-67-6
2-Iodobenzoyl chloride

: 294190-56-0
acetic acid 1-(2-(3,3-dimethyl-but-1-ynyl)-phenyl)-3-trimethylsilanyl-buta-1,2-dienyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 5.64 g / pyridine / CH₂Cl₂ / 12 h / 25 °C

2.1: 66 percent / Pd(PPh₃)4; CuI; n-BuNH₂ / tetrahydrofuran / 2 h / 25 °C

3.1: 83 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / 0 - 25 °C

4.1: CuI / diethyl ether

4.2: 71 percent / diethyl ether / 2 h / -78 - 25 °C

With pyridine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; N-butylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; 1.1: Substitution / 2.1: Substitution / 3.1: Addition / 4.1: Addition / 4.2: Acetylation;
DOI:10.1021/jo991876v