609-67-6

Basic information

• Product Name: 2-IODOBENZOYL CHLORIDE
• Synonyms: O-IODOBENZOYL CHLORIDE;2-iodo-benzoylchlorid;Benzoyl chloride, 2-iodo-;2-IODOBENZOYL CHLORIDE;2-Iodobenzoylchloride,97%;2-Iodobenzoyl chloride, 98+%;2-Iodobenzoic acid chloride;2-Iodobenzoyl chloride, 98+% 25GR
• CAS NO: 609-67-6
• Molecular Formula: C₇H₄ClIO
• Molecular Weight: 266.46
• EINECS: 210-196-1
• Product Categories: Organics;Acid Halides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 609-67-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 27-31 °C(lit.)
• Boiling Point: 105-106 °C1 mm Hg(lit.)
• Flash Point: >110°C
• Appearance: white to pinkish or pale yellow crystalline
• Density: 1.932
• Vapor Pressure: 0.00215mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: Store below +30°C.
• Solubility: soluble in Toluene
• Water Solubility: Reacts with water.
• Sensitive: Moisture & Light Sensitive
• BRN: 2042672
• CAS DataBase Reference: 2-IODOBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-IODOBENZOYL CHLORIDE(609-67-6)
• EPA Substance Registry System: 2-IODOBENZOYL CHLORIDE(609-67-6)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• F: 21-19
• TSCA: Yes
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 609-67-6(Hazardous Substances Data)

Usage

Chemical Description

2-Iodobenzoyl chloride is a reagent used in the synthesis of heterocycles.

Chemical Properties

white to pinkish or pale yellow crystalline

Uses

Different sources of media describe the Uses of 609-67-6 differently. You can refer to the following data:
1. 2-Iodobenzoyl chloride has been used in palladium-catalyzed synthesis of carbomethoxy functional group-induced isoindolin-1-ones, preparation of starting materials required for the synthesis of novel cyclic derivatives of pentavalent iodine, benziodazole oxides.
2. 2-Iodobenzoyl chloride has been used in:palladium-catalyzed synthesis of carbomethoxy functional group-induced isoindolin-1-onespreparation of starting materials required for the synthesis of novel cyclic derivatives of pentavalent iodine, benziodazole oxides

InChI:InChI=1/C7H4ClIO/c8-7(10)5-3-1-2-4-6(5)9/h1-4H

Upstream product

• 79-37-8 oxalyl dichloride 
• 591-50-4 iodobenzene 
• 1569633-54-0 (E)-2-(ethoxycarbonyl)vinyl 2-iodobenzoate 
• 615-37-2 ortho-methylphenyl iodide 
• 118-92-3 anthranilic acid 
• 75-09-2 dichloromethane 
• 88-67-5 2-Iodobenzoic acid 

Downstream Products

• 6933-33-1 (2-iodophenyl)(thiophen-2-yl)methanone 
• 51417-53-9 2-iodo-benzoic acid anhydride 
• 10568-20-4 tert-butyl 2-iodobenzoperoxoate 
• 1829-28-3 ethyl 2-iodobenzoate 
• 861308-16-9 3-chloro-5-(4-iodo-benzoylamino)-4-(2-iodo-benzoyloxy)-toluene 
• 2142-70-3 2-iodoacetophenone 
• 30989-24-3 bis(O-iodobenzoyl) peroxide 
• 3930-83-4 o-iodobenzamide 
• 103441-58-3 1-(2-iodophenyl)propan-1-one 
• 115049-47-3 2-dichloroiodanyl-benzoyl chloride 
• 15310-01-7 benodanil 
• 107624-39-5 2-iodophenyl 4-methylphenyl ketone 
• 25187-00-2 2-iodobenzophenone 
• 159824-61-0 N-(o-iodobenzoyl)prolinol 

Relevant articles and documents

Method for preparing axitinib and intermediates thereof

The invention discloses a method for preparing axitinib and intermediates thereof. A chemical name of the axitinib is N-methyl-2-[(3-(1E-2-(pyridine-2-yl)ethylene)-1H-indazole-6-yl)sulfur]benzamide, and a chemical formula of the axitinib is C22H18N4OS. The preparation process disclosed by the invention is simple in process, readily available in raw materials, economic, environmentally friendly, high in product yield and product purity, contributes to realizing industrialization, reduces the production cost and is suitable for mass production. The provided novel intermediates and the preparation method thereof have significance on the economic technology of the axitinib.

Copper-Catalyzed C(sp3)-S Bond and C(sp2)-S Bond Cross-Coupling of 2-(2-Iodobenzoyl) Substituted or 2-(2-Iodobenzyl) Substituted 1,2,3,4-Tetrahydroisoquinolines with Potassium Sulfide: Synthesis of Isoquinoline-Fused 1,3-Benzothiazine Scaffolds

The sulfuration reaction of 2-(2-iodobenzoyl) substituted, or 2-(2-iodobenzyl) substituted 1,2,3,4-tetrahydroisoquinolines with potassium sulfide proceeded in the presence of copper catalysts to give tetrahydroisoquinoline-fused 1,3-benzothiazine scaffolds in moderate to appropriate yields. This protocol provided an efficient and simple strategy to construct the corresponding benzothiazine derivatives via formation of C(sp3)-S bond and C(sp2)-S bond, which the C-S bonds formed via different routes in this reaction (traditional cross-coupling reaction via the cleavage of C-I bond and oxidative cross-coupling reaction via C(sp3)-H bond functionalization).

Palladium-catalyzed annulation reactions of methyl o-halobenzoates with azabicyclic alkenes: A general protocol for the construction of benzo[c]phenanthridine derivatives

The annulation reaction of methyl o-halobenzoates with azabicyclic alkenes proceeds efficiently to give the corresponding benzo[c]phenanthridine derivatives in good to excellent yields using a developed base-free methodology based on our preliminary studies. Thirty-seven application examples validate the compatibility of the present strategy with different groups, particularly with the electron-deficient ones, that are difficult to access using other traditional methods. In addition, annulation reactions with non-symmetric azabicyclic alkenes are achieved in high regioselectivity.