(S)-1-<1-<2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>>pyrrolidine

Base Information

Chemical Name:(S)-1-<1-<2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>>pyrrolidine
CAS No.:159497-69-5
Molecular Formula:C₂₈H₄₄N₂OSi
Molecular Weight:452.756
Hs Code.:

Synonyms:(S)-1-<1-<2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>>pyrrolidine

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Chemical Property of (S)-1-<1-<2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>>pyrrolidine

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Technology Process of (S)-1-<1-<2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>>pyrrolidine

There total 5 articles about (S)-1-<1-<2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>>pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 25150-61-2
pyrrolidine hydrochloride

: 159497-68-4
(S)-2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butanal

: 159497-69-5
(S)-1-<1-<2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>>pyrrolidine

Guidance literature:: With sodium cyanoborohydride; In methanol; for 1h; Ambient temperature;
DOI:10.1021/jo00101a042

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 159497-69-5
(S)-1-<1-<2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>>pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / imidazole / dimethylformamide / 2 h / 0 °C

2: 1.) DMSO, (COCl)2, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 15 min, 2.) 5 min

3: 50 percent / NaBH₃CN / methanol / 1 h / Ambient temperature

With 1H-imidazole; oxalyl dichloride; sodium cyanoborohydride; dimethyl sulfoxide; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00101a042

Reference yield:

: 137428-32-1
(2S)-2-[bis(phenylmethyl)amino]-1,4-butanediol

: 159497-69-5
(S)-1-<1-<2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>>pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / imidazole / dimethylformamide / 2 h / 0 °C

2: 1.) DMSO, (COCl)2, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 15 min, 2.) 5 min

3: 50 percent / NaBH₃CN / methanol / 1 h / Ambient temperature

With 1H-imidazole; oxalyl dichloride; sodium cyanoborohydride; dimethyl sulfoxide; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00101a042