Prednisolone phosphate

Base Information

• Chemical Name: Prednisolone phosphate
• CAS No.: 302-25-0
• Molecular Formula: C21H29O8P
• Molecular Weight: 440.43
• European Community (EC) Number: 206-120-1,204-722-9
• UNII: 752SY38R6C
• DSSTox Substance ID: DTXSID7047481
• Nikkaji Number: J193.710C
• Wikipedia: Prednisolone_sodium_phosphate
• Wikidata: Q27266327
• NCI Thesaurus Code: C61904
• RXCUI: 55062
• Pharos Ligand ID: M1MNT4JMX15U
• Metabolomics Workbench ID: 154991
• ChEMBL ID: CHEMBL1201231
• Mol file: 302-25-0.mol

Synonyms:Pediapred;prednisolone 21-phosphate sodium;prednisolone phosphate;prednisolone phosphate sodium;prednisolone phosphate, monosodium salt, (11beta)-isomer;prednisolone phosphate, sodium salt, (11beta)-isomer;prednisolone sodium phosphate;prednisolone-21-phosphate;Predsol

Chemical Property of Prednisolone phosphate

Chemical Property:

• Boiling Point: 674.8 °C at 760 mmHg
• Flash Point: 361.9 °C
• PSA: 156.83000
• LogP: 2.55100
• XLogP3: 0
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 4
• Exact Mass: 440.16000488
• Heavy Atom Count: 30
• Complexity: 889

Purity/Quality:

99.9% ^*data from raw suppliers

11,17-dihydroxy-21-(phosphonooxy)-Pregna-1,4-diene-3,20-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC12CC(C3C(C1CCC2(C(=O)COP(=O)(O)O)O)CCC4=CC(=O)C=CC34C)O
• Isomeric SMILES: C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)COP(=O)(O)O)O)CCC4=CC(=O)C=C[C@]34C)O
• Recent ClinicalTrials: Parasitic Ulcer Treatment Trial Pilot
• Recent EU Clinical Trials: A randomized, sham-controlled, double-blind study to evaluate the efficacy and safety of intrathecal (IT) OAV101 in patients with later onset Type 2 spinal muscular atrophy (SMA) who are ≥ 2 to < 18 years of age, treatment naive, sitting, and never ambulatory
• Uses: Glucocorticoid. 11,17-dihydroxy-21-(phosphonooxy)-Pregna-1,4-diene-3,20-dione is a steroid.

Technology Process of Prednisolone phosphate

There total 3 articles about Prednisolone phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

prednisolon (50-24-8,8056-11-9) → Prednisolone phosphate (302-25-0)

Guidance literature:

Multistep reaction; (i) POCl₃, THF, (ii) NaOH, MeOH;

DOI:10.1248/cpb.22.1439

Reference yield:

→ Prednisolone-21-phosphate (302-25-0)

Guidance literature:

Prednisolon, o-Phosphorsaeure;

Reference yield:

→ Prednisolon-21-dihydrogenphosphat (302-25-0)

Guidance literature:

Pregnadiendion (IV), H3PO4;

upstream raw materials:

prednisolon

Downstream raw materials:

prednisolone sodium phosphate

Refernces