Prednisolone sodium phosphate

Base Information

• Chemical Name: Prednisolone sodium phosphate
• CAS No.: 125-02-0
• Deprecated CAS: 1263143-23-2
• Molecular Formula: C₂₁H₂₈O₈P*Na
• Molecular Weight: 462.412
• Hs Code.: 2937290000
• European Community (EC) Number: 204-722-9
• UNII: IV021NXA9J
• DSSTox Substance ID: DTXSID2047480
• Nikkaji Number: J5.364C
• Wikipedia: Prednisolone_sodium_phosphate
• Wikidata: Q27280910
• NCI Thesaurus Code: C1402
• RXCUI: 55062
• Pharos Ligand ID: M1MNT4JMX15U
• ChEMBL ID: CHEMBL1201014
• Mol file: 125-02-0.mol

Synonyms:Pediapred;prednisolone 21-phosphate sodium;prednisolone phosphate;prednisolone phosphate sodium;prednisolone phosphate, monosodium salt, (11beta)-isomer;prednisolone phosphate, sodium salt, (11beta)-isomer;prednisolone sodium phosphate;prednisolone-21-phosphate;Predsol

Chemical Property of Prednisolone sodium phosphate

Chemical Property:

• Vapor Pressure: 4.17E-21mmHg at 25°C
• Boiling Point: 674.8 ºC at 760 mmHg
• Flash Point: 361.9 ºC
• PSA: 156.83000
• LogP: 2.55100
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Freely soluble in water, very slightly soluble in ethanol (96 per cent).
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 3
• Exact Mass: 484.12389338
• Heavy Atom Count: 32
• Complexity: 878

Purity/Quality:

99% ^*data from raw suppliers

Prednisolone disodium phosphate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC12CC(C3C(C1CCC2(C(=O)COP(=O)([O-])[O-])O)CCC4=CC(=O)C=CC34C)O.[Na+].[Na+]
• Isomeric SMILES: C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)COP(=O)([O-])[O-])O)CCC4=CC(=O)C=C[C@]34C)O.[Na+].[Na+]
• Recent ClinicalTrials: Parasitic Ulcer Treatment Trial Pilot
• Recent EU Clinical Trials: A randomized, sham-controlled, double-blind study to evaluate the efficacy and safety of intrathecal (IT) OAV101 in patients with later onset Type 2 spinal muscular atrophy (SMA) who are ≥ 2 to < 18 years of age, treatment naive, sitting, and never ambulatory
• Description: Prednisolone is a synthetic analog of the natural glucocorticoid corticosterone that has anti-inflammatory and immunsuppressive actions. It avidly binds both glucocorticoid and mineralocorticoid receptors (Kis = 2.4 and 37 nM). Prednisolone Phosphate, prepared as the sodium salt, is a water-soluble ester of the poorly soluble parent molecule, prednisolone. It is rapidly hydrolyzed in vivo to the parent molecule when administered intravenously. In addition, when given orally, prednisolone phosphate is more readily absorbed than prednisolone, resulting in a higher effective blood concentration of prednisolone.
• Uses: Prednisolone Sodium is a synthetic corticosteroid; metabolically interconvertible with prednisone. antiinflammatory
• Therapeutic Function: Glucocorticoid

Technology Process of Prednisolone sodium phosphate

There total 3 articles about Prednisolone sodium phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Prednisolone phosphate (302-25-0) → prednisolone sodium phosphate (125-02-0,2681-16-5,13926-42-6)

Guidance literature:

With sodium hydroxide; In water; at 20 - 25 ℃; pH=8 - 9.5; Temperature;

Reference yield:

→ prednisolone sodium phosphate (125-02-0,2681-16-5,13926-42-6)

Guidance literature:

Reference yield:

→ Prednisolon 21-phosphate mono-Natrium-Salz (125-02-0,2681-16-5,13926-42-6)

Guidance literature:

aus Prednisolon 21-dimorpholidophosphate mono Na Salz;

upstream raw materials:

Prednisolone phosphate

Refernces

• 1、 -. "Method for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor". . . Retrieved 2008/06/13.