(+)-(1R,αS)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-α-phenyl-1-isoquinolinemethanol

Base Information

• Chemical Name: (+)-(1R,αS)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-α-phenyl-1-isoquinolinemethanol
• CAS No.: 120142-63-4
• Molecular Formula: C₁₉H₂₃NO₃
• Molecular Weight: 313.397

Synonyms:(+)-(1R,αS)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-α-phenyl-1-isoquinolinemethanol

Chemical Property of (+)-(1R,αS)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-α-phenyl-1-isoquinolinemethanol

Chemical Property:

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Technology Process of (+)-(1R,αS)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-α-phenyl-1-isoquinolinemethanol

There total 10 articles about (+)-(1R,αS)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-α-phenyl-1-isoquinolinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(1S,10bS)-8,9-Dimethoxy-1-phenyl-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinolin-3-one (86970-91-4) → threo-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-α-phenyl-1-isoquinolinemethanol (86970-95-8,120142-66-7,17052-77-6,97101-12-7,97101-13-8,120142-63-4,120142-64-5,120142-65-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 14h; Ambient temperature;

DOI:10.1021/jo00169a054

Reference yield: 67.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (-)-(1R,αS)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-1-isoquinolinemethanol (120142-61-2) → (+)-(1R,αS)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-α-phenyl-1-isoquinolinemethanol (120142-63-4)

Guidance literature:

With hydrogen; nickel; In methanol; for 12h; under 2068.6 Torr; Ambient temperature;

DOI:10.1021/jo00274a044

Reference yield: 10.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (+/-)-threo-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-1-isoquinolinemethanol (120034-52-8) → (1S,10bS)-8,9-Dimethoxy-1-phenyl-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinoline (120034-54-0) + threo-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-α-phenyl-1-isoquinolinemethanol (86970-95-8,120142-66-7,17052-77-6,97101-12-7,97101-13-8,120142-63-4,120142-64-5,120142-65-6)

Guidance literature:

With hydrogen; nickel; In methanol; for 12h; under 2068.6 Torr; Ambient temperature;

DOI:10.1021/jo00274a044

upstream raw materials:

formaldehyd

(+/-)-threo-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-1-isoquinolinemethanol

(1S,10bS)-8,9-Dimethoxy-1-phenyl-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinolin-3-one

5-phenyloxazolidine-2,4-dione

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