2-chloro-7-hydroxy-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile

Base Information

Chemical Name:2-chloro-7-hydroxy-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
CAS No.:1272672-25-9
Molecular Formula:C₂₁H₁₄ClN₃O₄
Molecular Weight:407.813
Hs Code.:

Synonyms:2-chloro-7-hydroxy-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile

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Chemical Property of 2-chloro-7-hydroxy-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile

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Technology Process of 2-chloro-7-hydroxy-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile

There total 12 articles about 2-chloro-7-hydroxy-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.2%

: 1438835-17-6
ethyl 5-chloro-3-[(cyanoacetyl)amino]-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-1H-pyrrole-2-carboxylate

: 1272672-25-9
2-chloro-7-hydroxy-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; dimethyl sulfoxide; at 90 ℃; for 0.0333333h;
DOI:10.1021/ml400157g

Reference yield: 28.3%

: 259209-17-1
[2-hydroxy-3-(methyloxy)phenyl]boronic acid

: 1272672-24-8
1-(4-bromophenyl)-2-chloro-7-hydroxy-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile

: 1272672-25-9
2-chloro-7-hydroxy-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 160 ℃; for 0.666667h; microwave reactor;

Reference yield:

: 1272674-00-6
ethyl 3-(acetylamino)-1-(4-bromophenyl)-5-chloro-1H-pyrrole-2-carboxylate

: 1272672-25-9
2-chloro-7-hydroxy-1-[2'-hydroxy-3'-(methyloxy)-4-biphenylyl]-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; water / ethanol / 2 h / Reflux

2: triethylamine; dicyclohexyl-carbodiimide / acetonitrile / 24 h / 50 °C

3: sodium hydride / tetrahydrofuran; mineral oil / 20 - 50 °C

4: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.67 h / 160 °C / microwave reactor

With hydrogenchloride; water; sodium hydride; caesium carbonate; triethylamine; dicyclohexyl-carbodiimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; water; acetonitrile; mineral oil;