Technology Process of (2R,3R)-2-(benzyloxy)-3-fluoro-5-hexen-1-ol
There total 5 articles about (2R,3R)-2-(benzyloxy)-3-fluoro-5-hexen-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NaH / 1.) DMF/THF, 0 deg C, 2.) 25 deg C, 0.5 h
2: 2,4,6-trimethylpyridine / acetonitrile / 0.5 h / Ambient temperature
3: 1.) copper(II) chloride, potassium carbonate, 2.) sodium borohydride / 1.) water, RT, 2.0 h, 2.) acetonitrile, isopropyl alcohol, 25 deg C, 10 min
With
2,4,6-trimethyl-pyridine; sodium tetrahydroborate; sodium hydride; potassium carbonate; copper dichloride;
In
acetonitrile;
DOI:10.1021/jo00282a039
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NaH / 1.) DMF/THF, 0 deg C, 2.) 25 deg C, 0.5 h
2: 2,4,6-trimethylpyridine / acetonitrile / 0.5 h / Ambient temperature
3: 1.) copper(II) chloride, potassium carbonate, 2.) sodium borohydride / 1.) water, RT, 2.0 h, 2.) acetonitrile, isopropyl alcohol, 25 deg C, 10 min
With
2,4,6-trimethyl-pyridine; sodium tetrahydroborate; sodium hydride; potassium carbonate; copper dichloride;
In
acetonitrile;
DOI:10.1021/jo00282a039
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 100 percent / diisobutylaluminum hydride (DIBAH) / hexane; tetrahydrofuran / 0.5 h / -78 °C
2: 1.) NaH / 1.) DMF/THF, 0 deg C, 2.) 25 deg C, 0.5 h
3: 2,4,6-trimethylpyridine / acetonitrile / 0.5 h / Ambient temperature
4: 1.) copper(II) chloride, potassium carbonate, 2.) sodium borohydride / 1.) water, RT, 2.0 h, 2.) acetonitrile, isopropyl alcohol, 25 deg C, 10 min
With
2,4,6-trimethyl-pyridine; sodium tetrahydroborate; sodium hydride; diisobutylaluminium hydride; potassium carbonate; copper dichloride;
In
tetrahydrofuran; hexane; acetonitrile;
DOI:10.1021/jo00282a039
