4,4-dimethyl-2-oxazoline-N-Boc-L-selenocysteine methyl ester

Base Information

• Chemical Name: 4,4-dimethyl-2-oxazoline-N-Boc-L-selenocysteine methyl ester
• CAS No.: 862422-01-3
• Molecular Formula: C₂₀H₂₈N₂O₅Se
• Molecular Weight: 455.413
• Mol file: 862422-01-3.mol

Synonyms:4,4-dimethyl-2-oxazoline-N-Boc-L-selenocysteine methyl ester

Chemical Property of 4,4-dimethyl-2-oxazoline-N-Boc-L-selenocysteine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4-dimethyl-2-oxazoline-N-Boc-L-selenocysteine methyl ester

There total 5 articles about 4,4-dimethyl-2-oxazoline-N-Boc-L-selenocysteine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

4,5-dihydro-4,4-dimethyl-2-phenoxazole (19312-06-2) + methyl (2R)-2-[(tert-butoxycarbonyl)amino]-3-bromopropionate (175844-11-8,402726-50-5) → 4,4-dimethyl-2-oxazoline-N-Boc-L-selenocysteine methyl ester (862422-01-3)

Guidance literature:

4,5-dihydro-4,4-dimethyl-2-phenoxazole; With lithium selenate; In diethyl ether; at 0 ℃;

methyl (2R)-2-[(tert-butoxycarbonyl)amino]-3-bromopropionate; In diethyl ether; at 0 ℃; for 18h;

DOI:10.1039/b505299h

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 4,4-dimethyl-2-oxazoline-N-Boc-L-selenocysteine methyl ester (862422-01-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 94.3 percent / aq. NaOH / dioxane / 4.5 h / 5 - 20 °C

2.1: 72.3 percent / K₂CO₃ / dimethylformamide / 20 h / 0 °C

3.1: pyridine

4.1: NaBr

5.1: lithium selenolate / diethyl ether / 0 °C

5.2: 47 percent / diethyl ether / 18 h / 0 °C

With pyridine; sodium hydroxide; lithium selenate; potassium carbonate; sodium bromide; In 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1039/b505299h

Reference yield:

(S)-N-(tert-butoxycarbonyl)serine (3262-72-4) → 4,4-dimethyl-2-oxazoline-N-Boc-L-selenocysteine methyl ester (862422-01-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 72.3 percent / K₂CO₃ / dimethylformamide / 20 h / 0 °C

2.1: pyridine

3.1: NaBr

4.1: lithium selenolate / diethyl ether / 0 °C

4.2: 47 percent / diethyl ether / 18 h / 0 °C

With pyridine; lithium selenate; potassium carbonate; sodium bromide; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1039/b505299h

upstream raw materials:

4,5-dihydro-4,4-dimethyl-2-phenoxazole

methyl (2R)-2-[(tert-butoxycarbonyl)amino]-3-bromopropionate

di-tert-butyl dicarbonate

(S)-N-(tert-butoxycarbonyl)serine

Downstream raw materials:

2-tert-butoxycarbonylamino-3-[2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-phenylselanyl]-propionic acid