4,4-DIMETHYL-2-PHENYL-2-OXAZOLINE

Base Information

• Chemical Name: 4,4-DIMETHYL-2-PHENYL-2-OXAZOLINE
• CAS No.: 19312-06-2
• Molecular Formula: C11H13NO
• Molecular Weight: 175.23
• Hs Code.: 2934999090
• Mol file: 19312-06-2.mol

Synonyms:4,4-dimethyl-2-phenyl-4,5-dihydro-oxazole;4,5-dihydro-4,4-dimethyl-2-phenyl-2-oxazoline;2-phenyl-4,4-dimethyl-4,5-dihydrooxazole;oxazole,4,5-dihydro-4,4-dimethyl-2-phenyl;4,4-dimethyl-4,5-dihydro-2-phenyl oxazole;4,4-Dimethyl-2-phenyl-4,5-dihydro-1,3-oxazole;2-phenyl-4,4-dimethyl-4,5-dihydro-1,3-oxazole;4,5-dihydro-4,4-dimethyl-2-phenyloxazole;4,4-Dimethyl-2-phenyl-2-oxazoline;

Chemical Property of 4,4-DIMETHYL-2-PHENYL-2-OXAZOLINE

Chemical Property:

• Vapor Pressure: 0.0555mmHg at 25°C
• Melting Point: 20-24oC
• Refractive Index: n20/D 1.5322(lit.)
• Boiling Point: 241.5°Cat760mmHg
• PKA: 4.82±0.70(Predicted)
• Flash Point: 93.2°C
• PSA: 21.59000
• Density: 1.04g/cm³
• LogP: 1.67760

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,4-Dimethyl-2-phenyl-2-oxazoline 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4,4-Dimethyl-2-phenyl-2-oxazoline may be used in the synthesis of an ester-ammonium salt via rupture of oxazoline ring.

Technology Process of 4,4-DIMETHYL-2-PHENYL-2-OXAZOLINE

There total 73 articles about 4,4-DIMETHYL-2-PHENYL-2-OXAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzoyl chloride (98-88-4) + 2-Amino-2-methyl-1-propanol (124-68-5) → 4,5-dihydro-4,4-dimethyl-2-phenoxazole (19312-06-2)

Guidance literature:

benzoyl chloride; 2-Amino-2-methyl-1-propanol; In dichloromethane; at 20 ℃; for 18h;

With thionyl chloride; In dichloromethane; Further stages.;

DOI:10.1039/b600181e

Reference yield: 97.0%

2-Amino-2-methyl-1-propanol (124-68-5) + benzoic acid (65-85-0,8013-63-6) → 4,5-dihydro-4,4-dimethyl-2-phenoxazole (19312-06-2)

Guidance literature:

With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2005.10.068

Reference yield: 97.0%

N-(2-hydroxyl-1,1-dimethylethyl) benzamide (19312-05-1) → 4,5-dihydro-4,4-dimethyl-2-phenoxazole (19312-06-2)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); diisopropyl-carbodiimide; In 1,4-dioxane; for 5h; Heating;

DOI:10.1016/j.tetlet.2004.10.143

upstream raw materials:

N-(2-hydroxyl-1,1-dimethylethyl) benzamide

N-(chloro-tert-butyl)-benzamide

ethyl benzimidate hydrochloride

2-Amino-2-methyl-1-propanol

Downstream raw materials:

8,8-dichloro-5-dichloromethylene-3,3-dimethyl-8a-phenyl-tetrahydro-oxazolo[3,2-c][1,3]oxazin-7-one

3,4,4-trimethyl-2-phenyl-4,5-dihydro-oxazolium; iodide

N-tert-butyl-2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-benzamide

N-(2-methylallyl)benzamide

Refernces

• 1、 G?bel, Dominik,Rusch, Pascal,Duvinage, Daniel,Stauch, Tim,Bigall, Nadja-C.,Nachtsheim, Boris J.. "Substitution Effect on 2-(Oxazolinyl)-phenols and 1,2,5-Chalcogenadiazole -Annulated Derivatives: Emission-Color-Tunable, Minimalistic Excited-State Intramolecular Proton Transfer (ESIPT)-Based Luminophores". supporting information. p. 14333 - 14355. Retrieved 2021/10/20.
• 2、 Ramos, Robin,Zimbron, Jérémy M.,Thorimbert, Serge,Chamoreau, Lise-Marie,Munier, Annie,Botuha, Candice,Karaiskou, Anthi,Salmain, Michèle,Sobczak-Thépot, Jo?lle. "Insights into the antiproliferative mechanism of (C^N)-chelated half-sandwich iridium complexes". supporting information. p. 17635 - 17641. Retrieved 2020/12/30.