tert-butyl (2S)-2-((1R)-2-(3-methyl-4-nitroisoxazol-5-yl)-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

Base Information

• Chemical Name: tert-butyl (2S)-2-((1R)-2-(3-methyl-4-nitroisoxazol-5-yl)-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate
• CAS No.: 1459161-35-3
• Molecular Formula: C₂₁H₂₃N₃O₆
• Molecular Weight: 413.43

Synonyms:tert-butyl (2S)-2-((1R)-2-(3-methyl-4-nitroisoxazol-5-yl)-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

Chemical Property of tert-butyl (2S)-2-((1R)-2-(3-methyl-4-nitroisoxazol-5-yl)-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl (2S)-2-((1R)-2-(3-methyl-4-nitroisoxazol-5-yl)-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

There total 2 articles about tert-butyl (2S)-2-((1R)-2-(3-methyl-4-nitroisoxazol-5-yl)-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-(tert-butoxycarbonyl)pyrrol-2(5H)-one (141293-14-3) + 5-styryl-4-nitro-3-methylisoxazole (53557-94-1) → tert-butyl (2S)-2-((1R)-2-(3-methyl-4-nitroisoxazol-5-yl)-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate (1459161-35-3)

Guidance literature:

With C₃₂H₂₈F₆N₄O₃; In tetrahydrofuran; at 50 ℃; for 36h; Reagent/catalyst; enantioselective reaction;

DOI:10.1039/c3cc44059a

Reference yield:

N-(tert-butoxycarbonyl)pyrrol-2(5H)-one (141293-14-3) + 5-styryl-4-nitro-3-methylisoxazole (53557-94-1) → tert-butyl (2R)-2-((1S)-2-(3-methyl-4-nitroisoxazol-5-yl)-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate + tert-butyl 2-(2-(3-methyl-4-nitroisoxazol-5-yl)-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate + tert-butyl (2S)-2-((1R)-2-(3-methyl-4-nitroisoxazol-5-yl)-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate (1459161-35-3)

Guidance literature:

With QD-4; In dichloromethane; at 50 ℃; for 36h; Reagent/catalyst; Overall yield = 75 %; enantioselective reaction;

DOI:10.1039/c3cc44059a

Reference yield: 98.0%

tert-butyl (2S)-2-((1R)-2-(3-methyl-4-nitroisoxazol-5-yl)-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate (1459161-35-3) → (S)-5-((R)-2-(3-methyl-4-nitroisoxazol-5-yl)-1-phenylethyl)-1H-pyrrol-2(5H)-one (1459161-51-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.333333h;

DOI:10.1039/c3cc44059a

upstream raw materials:

N-(tert-butoxycarbonyl)pyrrol-2(5H)-one

5-styryl-4-nitro-3-methylisoxazole

Downstream raw materials:

(S)-5-((R)-2-(3-methyl-4-nitroisoxazol-5-yl)-1-phenylethyl)-1H-pyrrol-2(5H)-one

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