141293-14-3

Basic information

• Product Name: 2-OXO-2,5-DIHYDRO-PYRROLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 2-OXO-2,5-DIHYDRO-PYRROLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;N-BOC-PYRROL-2(5H)-ONE;1H-Pyrrole-1-carboxylic acid, 2,5-dihydro-2-oxo-, 1,1-diMethylethyl ester;tert-Butyl 2-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate;N-(tert-Butoxycarbonyl)-3-pyrrolin-2-one;tert-Butyl 2-oxo-3-pyrroline-1-carboxylate;tert-butyl 2-oxo-2H-pyrrole-1(5H)-carboxylate;2,5-dihydro-2-oxo-1H-Pyrrole-1-carboxylic acid 1,1-dimethylethyl ester
• CAS NO: 141293-14-3
• Molecular Formula: C₉H₁₃NO₃
• Molecular Weight: 183.2
• Mol File: 141293-14-3.mol
• Article Data: 15

Chemical Properties

• Melting Point: 67-68℃
• Boiling Point: 241.8±33.0 °C(Predicted)
• Appearance: /
• Density: 1.168±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.90±0.20(Predicted)
• CAS DataBase Reference: 2-OXO-2,5-DIHYDRO-PYRROLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-OXO-2,5-DIHYDRO-PYRROLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(141293-14-3)
• EPA Substance Registry System: 2-OXO-2,5-DIHYDRO-PYRROLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(141293-14-3)

Safety Data

• Hazardous Substances Data: 141293-14-3(Hazardous Substances Data)

Usage

General Description

2-OXO-2,5-DIHYDRO-PYRROLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is a chemical compound with the molecular formula C9H13NO3. It is a tert-butyl ester of 2-oxo-2,5-dihydro-pyrrole-1-carboxylic acid. 2-OXO-2,5-DIHYDRO-PYRROLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is often used as a building block in organic synthesis to create various pharmaceuticals, agrochemicals, and other chemical compounds. It is a colorless liquid with a molecular weight of 183.2 g/mol and a boiling point of 106-107°C. The chemical has been studied for its potential applications in drug discovery and development, as well as in the production of fine chemicals and intermediates.

Upstream product

• 409341-03-3 tert-butyl 4-hydroxy-2-oxopyrrolidine-1-carboxylate 
• 135884-31-0 N-boc-2-pyrroleboronic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 85909-08-6 tert-butyl 2-oxopyrrolidine-1-carboxylate 
• 141293-28-9 N-(tert-butoxycarbonyl)-2-[(tert-butyldimethylsilyl)oxy]pyrrole 
• 2043-21-2 acryloyl-1,3-oxazolidin-2-one 
• 4031-15-6 3-pyrrolin-2-one 
• 4248-19-5 tert-butyl carbazate 
• 109-97-7 pyrrole 

Downstream Products

• 1039356-74-5 1-(tert-butoxycarbonyl)-5-(1-trimethylsilanyloxy-cyclohexyl)-1H-pyrrol-2(5H)-one 
• 1034170-12-1 (5S)-1-(tert-butoxycarbonyl)-5-{(R)-trimethylsilanyloxy[(R)-(2,2-dimethyl-1,3-dioxolan-4-yl)](phenyl)methyl}-1H-pyrrol-2(5H)-one 
• 165728-30-3 4-(2-amino-phenylthio)-N-Boc-pyrrolidin-2-one 

Relevant articles and documents

N-(tert-Butoxycarbonyl)-2-(tert-butyldimethylsiloxy)pyrrole: A Promising Compound for Synthesis of Chiral Nonracemic Hydroxylated Pyrrolidine Derivatives

N-t-Boc-2-(tert-butyldimethylsiloxy)pyrrole has been synthesized from pyrrole and used to prepare enantiomerically pure pyrrolinones 5, 6, 15, and 16 and polyhydroxylated pyrrolidinones of type 11 and 12.

Short synthesis of pulchellalactam

tert -Butyl 4-methyl-2-oxo-2,5-dihydro-1 H -pyrrole-1-carboxylate 4 was synthesized by a short two-step procedure: regioselective 1,3-dipolar diazomethane cycloaddition to N -Boc-pyrrolinone 2 and thermolysis of the adduct. The compound 4 could be converted in one step into pulchellalactam. Copyright Taylor & Francis Group, LLC.

Syntheses of templates derived from pyrrolidine trans-lactams as potential serine protease inhibitors

The synthesis of templates derived from pyrrolidine trans-lactams as shown in the graphic is described.

N-Substituted tertiary and O-substituted quaternary carbon stereogenic centers by site-, diastereo- and enantioselective vinylogous Mannich reactions

A readily accessible small-molecule phosphine, derived from commercially available starting materials such as an enantiomerically pure amino acid, serves as the precursor to a Ag-based chiral complex that can be prepared and used in situ to promote a vari

Mild and rapid hydroxylation of aryl/heteroaryl boronic acids and boronate esters with N-oxides

Aryl and heteroaryl boronic acids and boronate esters are rapidly, often within minutes, transformed into the corresponding phenols by N-oxides in an open flask at ambient temperature. This transformation has broad compatibility with a variety of functional groups.