N-benzyl-3,4,5-trimethoxybenzamide

Base Information

• Chemical Name: N-benzyl-3,4,5-trimethoxybenzamide
• CAS No.: 3940-84-9
• Molecular Formula: C₁₇H₁₉NO₄
• Molecular Weight: 301.342
• European Community (EC) Number: 661-497-3
• Nikkaji Number: J3.508.841E
• Mol file: 3940-84-9.mol

Synonyms:N-benzyl-3,4,5-trimethoxybenzamide;3940-84-9;ChemDiv3_001221;Oprea1_369317;Oprea1_642406;SCHEMBL2919972;IUHYGONSJUAHBM-UHFFFAOYSA-N;HMS1476H11;STL355863;AKOS001596699;IDI1_020187;NCGC00172875-01;CS-0332454;SR-01000426713;SR-01000426713-1;BRD-K26463335-001-01-9;Z27749615

Chemical Property of N-benzyl-3,4,5-trimethoxybenzamide

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 301.13140809
• Heavy Atom Count: 22
• Complexity: 330

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1OC)OC)C(=O)NCC2=CC=CC=C2

Technology Process of N-benzyl-3,4,5-trimethoxybenzamide

There total 7 articles about N-benzyl-3,4,5-trimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,4,5-trimethoxy-benzaldehyde (86-81-7) + benzylamine (100-46-9) → N-benzyl-3,4,5-trimethoxybenzamide (3940-84-9)

Guidance literature:

With 3-mesityl-4-methylthiazol-3-ium bis((trifluoromethyl)sulfonyl)imide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 60 ℃; Temperature; Solvent; Flow reactor; Electrochemical reaction;

DOI:10.1021/acs.orglett.6b00339

Reference yield: 98.0%

3,4,5-Trimethoxybenzoyl chloride (4521-61-3) + benzylamine (100-46-9) → N-benzyl-3,4,5-trimethoxybenzamide (3940-84-9)

Guidance literature:

With triethylamine; calcium chloride; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2014.02.041

Reference yield: 78.0%

benzylamine hydrochloride (3287-99-8,39110-74-2,108321-65-9) + 3,4,5-trimethoxy-benzaldehyde (86-81-7) → N-benzyl-3,4,5-trimethoxybenzamide (3940-84-9)

Guidance literature:

With tert.-butylhydroperoxide; copper(II) ferrite; calcium carbonate; In water; acetonitrile; at 20 ℃; for 10h; Inert atmosphere;

DOI:10.1016/j.tet.2014.01.051

upstream raw materials:

3,4,5-Trimethoxybenzoyl chloride

benzylamine

benzylamine hydrochloride

3,4,5-trimethoxy-benzaldehyde

Downstream raw materials:

4-benzyl-5-(3,4,5-trimethoxyphenyl)-3-(2',3',4',6'-tetra-O-benzoyl-β-D-glucopyranosyl)-1,2,4-triazole

4-benzyl-5-(β-D-glucopyranosyl)-3-(3,4,5-trimethoxyphenyl)-1,2,4-triazole

5-(β-D-glucopyranosyl)-3-(3,4,5-trimethoxyphenyl)-1,2,4-triazoIe

N-benzyl-3,4,5-trimethoxythiobenzamide