N-(2-[N',N'-diethylamino]-5-[N''-(4-chlorophenylsulfonyl)amino]pyrimidin-4-yl)-4'-(pyrrolidin-1-ylcarbonyloxy)-L-phenylalanine tert-butyl ester

Base Information

Chemical Name:N-(2-[N',N'-diethylamino]-5-[N''-(4-chlorophenylsulfonyl)amino]pyrimidin-4-yl)-4'-(pyrrolidin-1-ylcarbonyloxy)-L-phenylalanine tert-butyl ester
CAS No.:630123-62-5
Molecular Formula:C₃₂H₄₁ClN₆O₆S
Molecular Weight:673.233
Hs Code.:

Synonyms:N-(2-[N',N'-diethylamino]-5-[N''-(4-chlorophenylsulfonyl)amino]pyrimidin-4-yl)-4'-(pyrrolidin-1-ylcarbonyloxy)-L-phenylalanine tert-butyl ester

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Chemical Property of N-(2-[N',N'-diethylamino]-5-[N''-(4-chlorophenylsulfonyl)amino]pyrimidin-4-yl)-4'-(pyrrolidin-1-ylcarbonyloxy)-L-phenylalanine tert-butyl ester

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Technology Process of N-(2-[N',N'-diethylamino]-5-[N''-(4-chlorophenylsulfonyl)amino]pyrimidin-4-yl)-4'-(pyrrolidin-1-ylcarbonyloxy)-L-phenylalanine tert-butyl ester

There total 5 articles about N-(2-[N',N'-diethylamino]-5-[N''-(4-chlorophenylsulfonyl)amino]pyrimidin-4-yl)-4'-(pyrrolidin-1-ylcarbonyloxy)-L-phenylalanine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 630123-60-3
N-(2-[N',N'-diethylamino]-5-aminopyrimidin-4-yl)-4'-(pyrrolidin-1-ylcarbonyloxy)-L-phenylalanine tert-butyl ester

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 630123-62-5
N-(2-[N',N'-diethylamino]-5-[N''-(4-chlorophenylsulfonyl)amino]pyrimidin-4-yl)-4'-(pyrrolidin-1-ylcarbonyloxy)-L-phenylalanine tert-butyl ester

Guidance literature:: With pyridine; at -20 - -15 ℃; for 4h;

Reference yield:

: 16874-12-7,87553-74-0
Tyr(tBu)

: 630123-62-5
N-(2-[N',N'-diethylamino]-5-[N''-(4-chlorophenylsulfonyl)amino]pyrimidin-4-yl)-4'-(pyrrolidin-1-ylcarbonyloxy)-L-phenylalanine tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-diethyl-N-isopropylamine / tetrahydrofuran

2: isopropyl alcohol

3: triethylamine / dichloromethane

4: palladium on activated charcoal; hydrogen / ethanol

5: pyridine

With pyridine; N,N-diethyl-N-isopropylamine; palladium on activated charcoal; hydrogen; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmcl.2013.03.010

Reference yield:

: C₁₇H₁₉ClN₄O₅

: 630123-62-5
N-(2-[N',N'-diethylamino]-5-[N''-(4-chlorophenylsulfonyl)amino]pyrimidin-4-yl)-4'-(pyrrolidin-1-ylcarbonyloxy)-L-phenylalanine tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: isopropyl alcohol

2: triethylamine / dichloromethane

3: palladium on activated charcoal; hydrogen / ethanol

4: pyridine

With pyridine; palladium on activated charcoal; hydrogen; triethylamine; In ethanol; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmcl.2013.03.010