C₂₁H₂₇N₃O₃

Base Information

Chemical Name:C₂₁H₂₇N₃O₃
CAS No.:1312779-99-9
Molecular Formula:C₂₁H₂₇N₃O₃
Molecular Weight:369.464
Hs Code.:

C<sub>21</sub>H<sub>27</sub>N<sub>3</sub>O<sub>3</sub>

Synonyms:C₂₁H₂₇N₃O₃

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Chemical Property of C₂₁H₂₇N₃O₃

Chemical Property:

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Technology Process of C₂₁H₂₇N₃O₃

There total 14 articles about C₂₁H₂₇N₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1232059-52-7
ethyl 6-chloro-5-methyl-pyrimidine-4-carboxylate

: 1312590-38-7
C₁₃H₁₉NO

: 1312779-99-9
C₂₁H₂₇N₃O₃

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; for 6h; Reflux;

Reference yield:

: 1159010-94-2
6-hydroxy-5-methyl-pyrimidine-4-carboxylic acid

: 1312779-99-9
C₂₁H₂₇N₃O₃

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / N,N-dimethyl-formamide / 1 h / Reflux

2: potassium carbonate / dichloromethane / 1 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 6 h / Reflux

With thionyl chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane;

Reference yield:

: 5205-39-0
ethyl glutaroyl chloride

: 1312779-99-9
C₂₁H₂₇N₃O₃

Guidance literature:: Multi-step reaction with 11 steps

1.1: copper(I) bromide; lithium bromide / tetrahydrofuran / 18 h / 0 °C / Inert atmosphere

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 50 °C

2.2: pH 1

3.1: potassium hydroxide; sodium tetrahydroborate / water / 2 h / 10 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

5.1: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C

5.2: -78 - 20 °C

6.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C

7.1: boron trifluoride diethyl etherate / acetonitrile / 18 h / 20 °C / Inert atmosphere

8.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

9.1: DAICEL Chiralpack AS-H / hexane; ethanol / Resolution of racemate

10.1: borane-THF / tetrahydrofuran / 18 h / 20 °C

11.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 6 h / Reflux

With dmap; sodium tetrahydroborate; borane-THF; lithium hydroxide monohydrate; boron trifluoride diethyl etherate; potassium tert-butylate; water; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; copper(I) bromide; lithium bromide; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; water; acetonitrile;