4,4-difluoro-N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}cyclohexanecarboxamide

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Chemical Name:4,4-difluoro-N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}cyclohexanecarboxamide
CAS No.:1262786-45-7
Molecular Formula:C₃₃H₄₂F₂N₄O
Molecular Weight:548.719
Hs Code.:

Synonyms:4,4-difluoro-N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}cyclohexanecarboxamide

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Chemical Property of 4,4-difluoro-N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}cyclohexanecarboxamide

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Technology Process of 4,4-difluoro-N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}cyclohexanecarboxamide

There total 4 articles about 4,4-difluoro-N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 122665-97-8
4,4-difluorocyclohexanecarboxylic acid

: 1262786-67-3
2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenyl-1-butanamine

: 1262786-45-7
4,4-difluoro-N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}cyclohexanecarboxamide

Guidance literature:: 4,4-difluorocyclohexanecarboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 0.166667h; Inert atmosphere;

2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenyl-1-butanamine; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1262786-66-2
2-methyl-4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile

: 1262786-45-7
4,4-difluoro-N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide; hydrogen / ethanol / 18 h / 50 °C / 2585.81 Torr

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 18 h / 20 °C

With ammonium hydroxide; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.01.030

Reference yield:

: 123064-05-1
3-cyano-3-methyl-3-phenylpropanoic acid ethyl ester

: 1262786-45-7
4,4-difluoro-N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C

2: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C

3: ammonium hydroxide; hydrogen / ethanol / 18 h / 50 °C / 2585.81 Torr

4: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 18 h / 20 °C

With ammonium hydroxide; hydrogen; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.01.030