2-methyl-4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile

Base Information

• Chemical Name: 2-methyl-4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile
• CAS No.: 1262786-66-2
• Molecular Formula: C₂₆H₃₀N₄
• Molecular Weight: 398.551

Synonyms:2-methyl-4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile

Chemical Property of 2-methyl-4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile

There total 2 articles about 2-methyl-4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

endo-1-(8-azabicyclo[3.2.1]oct-3-yl)-2-methyl-1H-benzimidazole (478696-46-7) + 3-cyano-3-phenyl-1-butanal (31004-60-1) → 2-methyl-4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile (1262786-66-2)

Guidance literature:

endo-1-(8-azabicyclo[3.2.1]oct-3-yl)-2-methyl-1H-benzimidazole; 3-cyano-3-phenyl-1-butanal; With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 18h;

With sodium hydrogencarbonate; In dichloromethane;

Reference yield:

3-cyano-3-methyl-3-phenylpropanoic acid ethyl ester (123064-05-1) → 2-methyl-4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile (1262786-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C

2: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C

With sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2011.01.030

Reference yield: 90.0%

2-methyl-4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile (1262786-66-2) → 2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenyl-1-butanamine (1262786-67-3)

Guidance literature:

With ammonium hydroxide; hydrogen; Raney nickel; In ethanol; water; at 50 ℃; for 18h; under 2585.81 Torr;

upstream raw materials:

endo-1-(8-azabicyclo[3.2.1]oct-3-yl)-2-methyl-1H-benzimidazole

3-cyano-3-phenyl-1-butanal

3-cyano-3-methyl-3-phenylpropanoic acid ethyl ester

Downstream raw materials:

2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenyl-1-butanamine

N-methyl-N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide

N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide

C₃₄H₄₄F₂N₄O

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1262786-66-2 2-methyl-4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile

Send

Send

Metric Ton KG G Pound L ML

Send

Send